Jha Abhijeet Kumar, Udayan Uday Kumar, Roy Prasoon Kumar, Amar Amar Kant Jha, Chaudhary R K P
Department of Skin & V.D, Patna Medical College and Hospital, Patna, Bihar, India.
J Cosmet Dermatol. 2018 Jun;17(3):313-318. doi: 10.1111/jocd.12394. Epub 2017 Aug 3.
Platelet-rich plasma has shown beneficial effects in the treatment of androgenic alopecia with its growth factor properties in accelerating the dermal papilla. Dermoscopy is a noninvasive method that allows the in vivo evaluation of microstructures not visible to the naked eye.
To ascertain the role of platelet-rich plasma (PRP) with microneedling, and to compare the pre- and post-treatment dermoscopic features in androgenetic alopecia. (AGA).
Patients with mild to moderate AGA, aged 18-45 years with Hamilton-Norwood score 1-5 were included in both study and control group. Dermoscopy was performed using Dermlite II hybrid m; 3Gen dermoscope at 10× magnification in polarized mode, and photographs were taken. Those not responding or those not having any new hair growth to conventional therapy for at least 1 year were included. The study group were given autologous platelet-rich plasma injections with microneedling over a period of 3 months at 3 weekly interval. Baseline and post-treatment photographs were taken.
Hair growth started after the first session. The patients' satisfaction was more than 75% in 18 patients, on patients' subjective hair growth assessment scale. In post-PRP-treated patients of AGA, increase in the number of vellus and total hairs, increased hair shaft diameter, and reduction in yellow dots were appreciated after 3 sessions. Hair pull test was negative after treatment in 14 patients (70%).
This study reinforces the importance of dermoscopy in not only aiding in the diagnosis, but also in evaluation of pre- and post-treatment response of AGA.
富血小板血浆凭借其生长因子特性在促进毛乳头生长方面对雄激素性脱发的治疗显示出有益效果。皮肤镜检查是一种非侵入性方法，可对肉眼不可见的微观结构进行体内评估。
确定富血小板血浆（PRP）联合微针治疗的作用，并比较雄激素性脱发（AGA）治疗前后的皮肤镜特征。
研究组和对照组均纳入年龄在18 - 45岁、Hamilton - Norwood评分为1 - 5级的轻至中度AGA患者。使用Dermlite II hybrid m；3Gen皮肤镜在偏振模式下以10倍放大倍数进行皮肤镜检查并拍照。纳入那些对常规治疗无反应或至少1年没有任何新毛发生长的患者。研究组在3个月内每隔3周接受一次自体富血小板血浆联合微针注射。拍摄基线和治疗后的照片。
第一次治疗后开始出现毛发生长。根据患者主观毛发生长评估量表，18名患者的满意度超过75%。在接受PRP治疗后的AGA患者中，3次治疗后可见毳毛和总毛发数量增加、毛干直径增大以及黄点减少。14名患者（70%）治疗后毛发牵拉试验为阴性。
本研究强化了皮肤镜检查不仅在AGA诊断中，而且在评估其治疗前后反应方面的重要性。
