身体活动与阿尔茨海默病高危成年人的更高认知功能有关。
Physical activity is associated with higher cognitive function among adults at risk for Alzheimer's disease.
机构信息
Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, United States.
Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, United States.
出版信息
Complement Ther Med. 2018 Feb;36:46-49. doi: 10.1016/j.ctim.2017.11.014. Epub 2017 Nov 24.
OBJECTIVE
We evaluated the specific association between physical activity and cognitive function among a national sample of the broader U.S. adult population with a family history of Alzheimer's disease.
METHODS
Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used to identify 219 older adults, ages 60-85, with a family history of Alzheimer's disease. The Digit Symbol Substitution Test (DSST) was used to assess cognitive function, with physical activity assessed via a validated questionnaire.
RESULTS
In an unadjusted model, older adults, who had at least one blood relative with Alzheimer's disease, had greater cognitive function when meeting MVPA guidelines in comparison to their inactive counterparts (β=9.6; 95% CI: 4.6-14.7; P=0.001). After adjustments, results were attenuated, but still statistically significant (8.5; 95% CI: 4.0-13.0; P=0.001).
CONCLUSION
In this national sample of individuals at risk for Alzheimer's disease, meeting physical activity guidelines was associated with higher cognitive function.
目的
我们评估了具有阿尔茨海默病家族史的更广泛的美国成年人群体中，体力活动与认知功能之间的特定关联。
方法
使用 1999-2002 年全国健康和营养检查调查（NHANES）的数据，确定了 219 名年龄在 60-85 岁之间、有阿尔茨海默病家族史的老年人。数字符号替换测试（DSST）用于评估认知功能，体力活动则通过经过验证的问卷进行评估。
结果
在未调整的模型中，与不活动的同龄人相比，至少有一位有血缘关系的阿尔茨海默病患者的老年人，当他们符合中高强度体力活动指南时，认知功能更高（β=9.6；95%置信区间：4.6-14.7；P=0.001）。调整后，结果虽然减弱，但仍具有统计学意义（8.5；95%置信区间：4.0-13.0；P=0.001）。
结论
在这个有患阿尔茨海默病风险的个体的全国性样本中，符合体力活动指南与更高的认知功能相关。
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