Grace G C, Dusting G J, Kemp B E, Martin T J
University of Melbourne, Department of Physiology, Parkville, Victoria, Australia.
Br J Pharmacol. 1987 Aug;91(4):729-33. doi: 10.1111/j.1476-5381.1987.tb11270.x.
1 Acetylcholine and rat calcitonin gene-related peptide (CGRP) produced a relaxation in rat isolated aortic rings which was entirely dependent on the presence of the endothelium. 2 In the absence of any exogenous vasodilator agent, the cyclic guanosine monophosphate (cyclic GMP) content was higher in rings with endothelium than in those without. 3 The vasorelaxation produced by acetylcholine and sodium nitroprusside was accompanied by increases in cyclic GMP in the smooth muscle, whereas that produced by CGRP was not accompanied by cyclic GMP accumulation. 4 Therefore, it appears unlikely that CGRP releases an endothelium-derived relaxing factor similar to that released by acetylcholine.
1 乙酰胆碱和大鼠降钙素基因相关肽（CGRP）可使大鼠离体主动脉环舒张，这种舒张完全依赖于内皮的存在。2 在没有任何外源性血管舒张剂的情况下，有内皮的主动脉环中环磷酸鸟苷（cGMP）含量高于无内皮的主动脉环。3 乙酰胆碱和硝普钠引起的血管舒张伴随着平滑肌中cGMP的增加，而CGRP引起的血管舒张并未伴随着cGMP的积累。4 因此，CGRP似乎不太可能释放类似于乙酰胆碱释放的内皮源性舒张因子。
