Morsel A M, Dhar M, Hulstijn W, Temmerman A, Morrens M, Sabbe B
Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium; Biological Psychology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.
Clin Neurophysiol. 2017 Apr;128(4):520-528. doi: 10.1016/j.clinph.2016.12.006. Epub 2016 Dec 18.
Patients with bipolar disorder (BD) are reported to have difficulties with inhibition, even in a euthymic state. However, the literature on cortical activity associated with response inhibition in BD remains ambiguous. This study investigates inhibition in euthymic BD using electrophysiological measures, while controlling for effects of specific medications.
Twenty patients with BD were compared with eighteen healthy controls on a Go/NoGo task while electroencephalogram was recorded. Behavioral and event-related potential (ERP) measurements were analyzed for the two groups. Medication effects were controlled for in the analysis.
Patients with BD had marginally reduced NoGo N2 amplitudes and increased NoGo P3 amplitudes compared with healthy controls when patients using benzodiazepines were excluded from the study. No behavioral differences between the groups were found.
Reduced NoGo N2 amplitudes in BD reflect aberrant conflict detection, an early stage of the inhibition process. In addition, increased NoGo P3 amplitudes in BD despite normal task performance reflect an overactive cortical system during a simple inhibition task.
Difficulties in early stages of inhibition in BD appear to have been compensated by increased cortical activation. This study extends current knowledge regarding cortical activations relating to inhibition in BD.
据报道，双相情感障碍（BD）患者即使在心境正常状态下也存在抑制困难。然而，关于BD中与反应抑制相关的皮质活动的文献仍不明确。本研究使用电生理测量方法，在控制特定药物影响的同时，调查心境正常的BD患者的抑制情况。
20名BD患者与18名健康对照者在进行Go/NoGo任务时记录脑电图。对两组的行为和事件相关电位（ERP）测量结果进行分析。分析中控制了药物影响。
当排除使用苯二氮䓬类药物的患者后，与健康对照者相比，BD患者的NoGo N2波幅略有降低，NoGo P3波幅增加。两组之间未发现行为差异。
BD患者NoGo N2波幅降低反映了异常的冲突检测，这是抑制过程的早期阶段。此外，尽管任务表现正常，但BD患者NoGo P3波幅增加反映了在简单抑制任务期间皮质系统过度活跃。
BD患者在抑制早期阶段的困难似乎已通过增加皮质激活得到补偿。本研究扩展了当前关于BD中与抑制相关的皮质激活的知识。
