Zhou Siying, Zhang Sijie, Shen Hongyu, Chen Wei, Xu Hanzi, Chen Xiu, Sun Dawei, Zhong Shanliang, Zhao Jianhua, Tang Jinhai
1 The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China.
Tumour Biol. 2017 Feb;39(2):1010428317691680. doi: 10.1177/1010428317691680.
Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers.
姜黄素是姜黄和咖喱中的主要黄色色素及香料，是一种强大的抗癌剂。姜黄素的抗肿瘤活性包括抑制肿瘤增殖、血管生成、侵袭和转移，诱导肿瘤凋亡，提高化疗敏感性，以及调节细胞周期和癌症干细胞，这表明姜黄素可能通过调节各种癌症进展具有强大的治疗潜力。据报道，作为小的非编码RNA分子的微小RNA与癌症进展相关，其可受姜黄素调节。失调的微小RNA通过调节靶基因的表达进而影响多种癌症相关信号通路，在肿瘤生物学中发挥重要作用。在本综述中，我们聚焦于姜黄素通过调节多种微小RNA的表达对各种癌症进展的抑制作用。姜黄素诱导的微小RNA失调可能激活或失活一组信号通路，如Akt、Bcl-2、PTEN、p53、Notch和Erbb信号通路。更好地理解姜黄素与微小RNA之间的关系可能为各种癌症提供潜在的治疗靶点。
