生长分化因子11的多功能性与矛盾性。
The versatility and paradox of GDF 11.
作者信息
Jamaiyar A, Wan W, Janota D M, Enrick M K, Chilian W M, Yin L
机构信息
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA; School of Biomedical Sciences, Kent State University, Kent, OH, USA.
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA; Department of Cardiology, Renmin Hospital of Wuhan University, Hubei, China.
出版信息
Pharmacol Ther. 2017 Jul;175:28-34. doi: 10.1016/j.pharmthera.2017.02.032. Epub 2017 Feb 14.
In addition to its roles in embryonic development, Growth and Differentiation Factor 11 (GDF 11) has recently drawn much interest about its roles in other processes, such as aging. GDF 11 has been shown to play pivotal roles in the rescue of the proliferative and regenerative capabilities of skeletal muscle, neural stem cells and cardiomyocytes. We would be remiss not to point that some controversy exists regarding the role of GDF 11 in biological processes and whether it will serve as a therapeutic agent. The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia. Based on these studies, GDF 11 is a promising candidate to serve as a novel biomarker of diseases. This brief review gives a detailed and concise view of the regulation and functions of GDF 11 and its roles in development, neurogenesis and erythropoiesis as well as the prospect of using this protein as an indicator of cardiac health and aging.
除了在胚胎发育中的作用外，生长分化因子11（GDF 11）最近在其他过程中的作用，如衰老，引起了人们极大的兴趣。GDF 11已被证明在挽救骨骼肌、神经干细胞和心肌细胞的增殖和再生能力方面发挥关键作用。我们必须指出，关于GDF 11在生物过程中的作用以及它是否会成为一种治疗剂，存在一些争议。最新研究表明，循环GDF 11水平与心血管疾病、癌症和尿毒症患者的预后相关。基于这些研究，GDF 11有望成为一种新型疾病生物标志物。这篇简短的综述详细而简洁地阐述了GDF 11的调控、功能及其在发育、神经发生和红细胞生成中的作用，以及将这种蛋白质用作心脏健康和衰老指标的前景。
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