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激动素通过调节角质形成细胞分化标志物改善皮肤屏障功能。

Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers.

作者信息

An Sungkwan, Cha Hwa Jun, Ko Jung-Min, Han Hyunjoo, Kim Su Young, Kim Kyung-Suk, Lee Song Jeong, An In-Sook, Kim Sangwon, Youn Hae Jeong, Ahn Kyu Joong, Kim Soo-Yeon

机构信息

Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul, Korea.

KISCS Incorporated, Cheongju, Korea.

出版信息

Ann Dermatol. 2017 Feb;29(1):6-12. doi: 10.5021/ad.2017.29.1.6. Epub 2017 Feb 2.

DOI:10.5021/ad.2017.29.1.6
PMID:28223740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5318528/
Abstract

BACKGROUND

Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier.

OBJECTIVE

We examined whether kinetin induces skin barrier functions and .

METHODS

To evaluate the efficacy of kinetin at the cellular level, expression of keratinocyte differentiation markers was assessed. Moreover, we examined the clinical efficacy of kinetin by evaluating skin moisture, transepidermal water loss (TEWL), and skin surface roughness in patients who used kinetin-containing cream. We performed quantitative real-time polymerase chain reaction to measure the expression of keratinocyte differentiation markers in HaCaT cells following treatment. A clinical trial was performed to assess skin moisture, TEWL, and evenness of skin texture in subjects who used kinetin-containing cream for 4 weeks.

RESULTS

Kinetin increased involucrin, and keratin 1 mRNA in HaCaT cells. Moreover, use of a kinetin-containing cream improved skin moisture and TEWL while decreasing roughness of skin texture.

CONCLUSION

Kinetin induced the expression of keratinocyte differentiation markers, suggesting that it may affect differentiation to improve skin moisture content, TEWL, and other signs of skin aging. Therefore, kinetin is a potential new component for use in cosmetics as an anti-aging agent that improves the barrier function of skin.

摘要

背景

激动素是一种调节生长和分化的植物激素。角质形成细胞是表皮的基本组成部分，其功能是维持皮肤屏障。

目的

我们研究了激动素是否能诱导皮肤屏障功能以及……

方法

为了在细胞水平评估激动素的功效，我们评估了角质形成细胞分化标志物的表达。此外，我们通过评估使用含激动素乳膏的患者的皮肤水分、经表皮水分流失（TEWL）和皮肤表面粗糙度，来检测激动素的临床疗效。我们进行了定量实时聚合酶链反应，以测量处理后HaCaT细胞中角质形成细胞分化标志物的表达。进行了一项临床试验，以评估使用含激动素乳膏4周的受试者的皮肤水分、TEWL和皮肤质地均匀度。

结果

激动素增加了HaCaT细胞中兜甲蛋白和角蛋白1的mRNA表达。此外，使用含激动素的乳膏可改善皮肤水分和TEWL，同时降低皮肤质地的粗糙度。

结论

激动素诱导角质形成细胞分化标志物的表达，表明它可能影响分化以改善皮肤水分含量、TEWL和其他皮肤老化迹象。因此，激动素是一种潜在的新型化妆品成分，可作为改善皮肤屏障功能的抗衰老剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/cc8f1b39f294/ad-29-6-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/e1cf3575c63a/ad-29-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/2da51f2a1042/ad-29-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/e6b517255a13/ad-29-6-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/d8dc52d30f2c/ad-29-6-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/c761142c6673/ad-29-6-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/cc8f1b39f294/ad-29-6-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/e1cf3575c63a/ad-29-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/2da51f2a1042/ad-29-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/e6b517255a13/ad-29-6-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/d8dc52d30f2c/ad-29-6-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/c761142c6673/ad-29-6-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/5318528/cc8f1b39f294/ad-29-6-g006.jpg

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