Ahmed Anwar E, Alharbi Abdulrahman G, Alsadhan Mohannad A, Almuzaini Alaa S, Almuzaini Hanin S, Ali Yosra Z, Jazieh Abdul-Rahman
King Abdullah International Medical Research Center (KAIMRC); College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences.
College of Medicine, Imam Abdulrahman Al Faisal University, Dammam.
Breast Cancer (Dove Med Press). 2017 Feb 9;9:51-58. doi: 10.2147/BCTT.S125206. eCollection 2017.
The protocols for treatment, along with many adverse effects, can strongly affect cancer patients' quality of life (QoL). As there is limited research on the QoL of Saudi Arabian women being treated for breast cancer, the purpose of this study was to identify the predictors of poor QoL in a sample of Saudi women with breast cancer.
A cross-sectional study was conducted on 145 Saudi women with breast cancer who attended the Oncology Outpatient Clinic at King Abdulaziz Medical City, Riyadh for routine follow-up. Sociodemographic and clinical data were collected for each patient, and a Medical Outcome Study Health Survey 36-Item Short Form (SF-36) instrument was used to assess QoL.
Of 145 breast cancer patients studied, 42.1% had a family history of cancer and 52.4% were newly diagnosed cancer patients (first-year-after-cancer diagnosis). According to linear regression analyses, cancer patients with metastasis tended to have pain, along with poor physical function, little vitality, and poor general health (a decrease in SF-36 scores of 22.9, 15.0, 19.4, and 16.9, respectively). Regular exercise was a positive predictor of poor general health (an increase in the SF-36 score of 8.2). Patients with first-year-after-cancer diagnoses tended to have poor emotional well-being (a decrease in the SF-36 score of 8.5).
In breast cancer patients, regular exercise was a significant positive predictor of better general health. Breast cancer patients with multiple tumors, metastasis, or fever tended to experience significantly poor QoL in several SF-36 domains. Clearly, a routine assessment of QoL in breast cancer patients is important.
治疗方案以及许多不良反应会对癌症患者的生活质量（QoL）产生重大影响。由于针对沙特阿拉伯乳腺癌女性患者生活质量的研究有限，本研究旨在确定沙特乳腺癌女性样本中生活质量差的预测因素。
对145名在利雅得阿卜杜勒阿齐兹国王医疗城肿瘤门诊接受常规随访的沙特乳腺癌女性进行了横断面研究。收集了每位患者的社会人口统计学和临床数据，并使用医学结局研究健康调查简表36项（SF - 36）工具评估生活质量。
在145名接受研究的乳腺癌患者中，42.1%有癌症家族史，52.4%是新诊断的癌症患者（癌症诊断后第一年）。根据线性回归分析，发生转移的癌症患者往往伴有疼痛，以及身体功能差、活力低和总体健康状况不佳（SF - 36评分分别下降22.9、15.0、19.4和16.9）。经常锻炼是总体健康状况不佳的一个正向预测因素（SF - 36评分增加8.2）。癌症诊断后第一年的患者往往情绪健康状况不佳（SF - 36评分下降8.5）。
在乳腺癌患者中，经常锻炼是总体健康状况较好的一个重要正向预测因素。患有多个肿瘤、发生转移或发热的乳腺癌患者在SF - 36的几个领域中往往生活质量显著较差。显然，对乳腺癌患者的生活质量进行常规评估很重要。
