Twijnstra A, Boon P J, Lormans A C, ten Velde G P
Department of Neurology, Academic Hospital Maastricht, University of Limburg, The Netherlands.
Eur J Cancer Clin Oncol. 1987 Jul;23(7):983-6. doi: 10.1016/0277-5379(87)90345-2.
This study is concerned with effects of prophylactic cranial irradiation on neurological and mental functioning of patients with small cell cancer of the lung. Results are reported of a pilot study in two parts. In a prospective clinical-neurological study, 14 patients with small cell cancer of the lung were evaluated with standard neurological and bedside mental status examinations, before and after irradiation. Their performance was compared with evaluation results of seven small cell cancer of the lung patients who received no irradiation. Dysfunctions were exclusively found in the irradiated patients, which are interpreted as a contributional effect of prophylactic cranial irradiation. Results are reported of further neuropsychological investigation in a sample of five prophylactic cranial irradiation patients. The presence of a rather specific pattern of neuropsychic deficits was confirmed. Areas of malfunctioning were described with some clinical and research implications.
本研究关注预防性颅脑照射对小细胞肺癌患者神经和心理功能的影响。报告了一项分为两部分的初步研究结果。在一项前瞻性临床神经学研究中，对14例小细胞肺癌患者在照射前后进行了标准神经学和床边精神状态检查评估。将他们的表现与7例未接受照射的小细胞肺癌患者的评估结果进行了比较。功能障碍仅在接受照射的患者中发现，这被解释为预防性颅脑照射的促成效应。报告了对5例接受预防性颅脑照射患者样本进行进一步神经心理学调查的结果。证实了存在一种相当特定的神经精神缺陷模式。描述了功能失常的领域及其一些临床和研究意义。
