Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Department of Gynecology and Obstetrics, University of Sao Paulo Medical School, Sao Paulo, Brazil.
BJOG. 2017 Mar;124(4):606-611. doi: 10.1111/1471-0528.14390. Epub 2016 Nov 7.
Lactobacilli are the most abundant vaginal bacteria in women. They inhibit binding of other bacteria to epithelial cells and produce lactic acid that kills or inhibits the growth of many other bacteria. Lactic acid blocks histone deacetylases, thereby enhancing gene transcription and DNA repair. Lactic acid induces autophagy in epithelial cells to degrade intracellular microorganisms and promote homeostasis. Lactobacilli are tolerated by vaginal epithelial cells and inhibit induction of pro-inflammatory cytokines. Emotional stress may reduce lactobacilli abundance in the vaginal microbiota and enhance inflammation. The ability of lactobacilli to inhibit infection without inducing inflammation may maximise fecundity and successful pregnancy outcome in women.
Lactobacilli prevent infection without inducing inflammation to maximise fertility and pregnancy outcome.
乳杆菌是女性阴道中最丰富的细菌。它们抑制其他细菌与上皮细胞的结合，并产生乳酸，杀死或抑制许多其他细菌的生长。乳酸阻断组蛋白去乙酰化酶，从而增强基因转录和 DNA 修复。乳酸诱导上皮细胞自噬，以降解细胞内微生物并促进体内平衡。乳杆菌被阴道上皮细胞耐受，并抑制促炎细胞因子的诱导。情绪压力可能会降低阴道微生物群中的乳杆菌丰度并增强炎症。乳杆菌抑制感染而不引起炎症的能力可以最大限度地提高女性的生育能力和成功妊娠结局。
