溶瘤麻疹病毒的临床试验：现状与未来展望。
Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects.
机构信息
MD Anderson Cancer Center, Division of Cancer Medicine, 1400 Holcombe Blvd, Unit 0463, Houston, TX 77030, USA.
Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
出版信息
Curr Cancer Drug Targets. 2018;18(2):177-187. doi: 10.2174/1568009617666170222125035.
Abstract
Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically engineered to express the human carcinoembryonic antigen (MV-CEA virus) or the human sodium iodide symporter (MV-NIS virus) and are currently being tested in clinical trials against ovarian cancer, glioblastoma multiforme, multiple myeloma, mesothelioma, head and neck cancer, breast cancer and malignant peripheral nerve sheath tumors. This review describes the basic and preclinical data that facilitated the clinical translation of MV-Edm strains, and summarizes the clinical results of this oncolytic platform to date. Furthermore, we discuss the latest clinically relevant MV-Edm vector developments and creative strategies for future translational steps.
摘要
减毒 Edmonston 谱系麻疹病毒（MV-Edm）疫苗株可以优先感染和溶解多种癌细胞。溶瘤 MV-Edm 衍生物经过基因工程改造，可表达人癌胚抗原（MV-CEA 病毒）或人钠碘同向转运体（MV-NIS 病毒），目前正在临床试验中针对卵巢癌、胶质母细胞瘤、多发性骨髓瘤、间皮瘤、头颈部癌、乳腺癌和恶性外周神经鞘瘤进行测试。这篇综述描述了促进 MV-Edm 株临床转化的基础和临床前数据，并总结了迄今为止该溶瘤平台的临床结果。此外，我们还讨论了最新的临床相关 MV-Edm 载体发展和未来转化步骤的创新策略。
相似文献
1
Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects.溶瘤麻疹病毒的临床试验：现状与未来展望。
Curr Cancer Drug Targets. 2018;18(2):177-187. doi: 10.2174/1568009617666170222125035.
2
Clinical testing of engineered oncolytic measles virus strains in the treatment of cancer: an overview.工程化溶瘤麻疹病毒株治疗癌症的临床试验综述。
Curr Opin Mol Ther. 2009 Feb;11(1):43-53.
3
Engineered measles virus as a novel oncolytic therapy against prostate cancer.工程化麻疹病毒作为一种新型的抗前列腺癌溶瘤疗法。
Prostate. 2009 Jan 1;69(1):82-91. doi: 10.1002/pros.20857.
4
Measles to the Rescue: A Review of Oncolytic Measles Virus.麻疹来救援：溶瘤性麻疹病毒综述
Viruses. 2016 Oct 22;8(10):294. doi: 10.3390/v8100294.
5
Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma.工程化麻疹病毒作为一种用于肝细胞癌的新型溶瘤病毒治疗系统。
Hepatology. 2006 Dec;44(6):1465-77. doi: 10.1002/hep.21437.
6
Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter.使用表达癌胚抗原和碘化钠同向转运体的麻疹病毒对卵巢癌进行双重治疗。
Clin Cancer Res. 2006 Mar 15;12(6):1868-75. doi: 10.1158/1078-0432.CCR-05-1803.
7
Attenuated oncolytic measles virus strains as cancer therapeutics.减毒溶瘤麻疹病毒株作为癌症治疗剂。
Curr Pharm Biotechnol. 2012 Jul;13(9):1732-41. doi: 10.2174/138920112800958896.
8
Effective radiovirotherapy for malignant gliomas by using oncolytic measles virus strains encoding the sodium iodide symporter (MV-NIS).溶瘤麻疹病毒株通过编码钠碘同向转运体（MV-NIS）对恶性脑胶质瘤的放射病毒治疗作用。
Hum Gene Ther. 2012 Apr;23(4):419-27. doi: 10.1089/hum.2011.158. Epub 2012 Mar 9.
9
Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy.表达钠碘转运体的麻疹病毒在碘非亲和性间变性甲状腺癌中的临床前疗效：一种允许无创成像和放射性碘治疗的新型治疗剂。
Cancer Gene Ther. 2012 Sep;19(9):659-65. doi: 10.1038/cgt.2012.47. Epub 2012 Jul 13.
10
Noninvasive imaging and radiovirotherapy of prostate cancer using an oncolytic measles virus expressing the sodium iodide symporter.利用表达钠碘同向转运体的溶瘤麻疹病毒进行前列腺癌的无创成像和放射病毒治疗。
Mol Ther. 2009 Dec;17(12):2041-8. doi: 10.1038/mt.2009.218. Epub 2009 Sep 22.
引用本文的文献
1
Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer's defenses.病毒战：释放工程化溶瘤病毒以智取癌症防御。
Front Immunol. 2025 Aug 25;16:1618751. doi: 10.3389/fimmu.2025.1618751. eCollection 2025.
2
Acute induction of IFNα is responsible for the attenuation of the live measles vaccine.IFNα的急性诱导是导致减毒活麻疹疫苗效力减弱的原因。
bioRxiv. 2025 Jun 9:2025.06.09.658652. doi: 10.1101/2025.06.09.658652.
3
Immunotherapy for High-Grade Gliomas.高级别胶质瘤的免疫治疗
Cancers (Basel). 2025 May 31;17(11):1849. doi: 10.3390/cancers17111849.
4
The multiverse of CD46 and oncologic interactions.CD46与肿瘤学相互作用的多元领域。
J Clin Invest. 2025 May 1;135(9). doi: 10.1172/JCI188355.
5
Production of Oncolytic Measles Virus in Vero Cells: Impact of Culture Medium and Multiplicity of Infection.在非洲绿猴肾细胞中生产溶瘤性麻疹病毒：培养基和感染复数的影响。
Viruses. 2024 Nov 6;16(11):1740. doi: 10.3390/v16111740.
6
Developing a potent vaccine against : critical considerations and challenges.开发针对……的有效疫苗：关键考量与挑战
Expert Rev Mol Med. 2024 Nov 25;27:e12. doi: 10.1017/erm.2024.19.
7
Innovative strategies in genitourinary cancer: the role of oncolytic viruses.泌尿生殖系统癌症的创新策略：溶瘤病毒的作用
Front Oncol. 2024 Oct 11;14:1461324. doi: 10.3389/fonc.2024.1461324. eCollection 2024.
8
An Unconventional Case Study of Neoadjuvant Oncolytic Virotherapy for Recurrent Breast Cancer.复发性乳腺癌新辅助溶瘤病毒疗法的非常规病例研究
Vaccines (Basel). 2024 Aug 23;12(9):958. doi: 10.3390/vaccines12090958.
9
The emerging field of viroimmunotherapy for pediatric brain tumors.小儿脑瘤病毒免疫治疗的新兴领域。
Neuro Oncol. 2024 Nov 4;26(11):1981-1993. doi: 10.1093/neuonc/noae160.
10
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment.溶瘤麻疹病毒、巨噬细胞和癌细胞之间的相互作用诱导促炎肿瘤微环境。
Oncoimmunology. 2024 Jul 10;13(1):2377830. doi: 10.1080/2162402X.2024.2377830. eCollection 2024.
本文引用的文献
1
Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment.麻疹病毒株联合抗程序性死亡蛋白1（PD-1）抗体阻断的免疫病毒疗法可增强胶质母细胞瘤治疗中的抗肿瘤活性。
Neuro Oncol. 2017 Apr 1;19(4):493-502. doi: 10.1093/neuonc/now179.
2
MiR-31 and miR-128 regulates poliovirus receptor-related 4 mediated measles virus infectivity in tumors.miR-31 和 miR-128 调节脊髓灰质炎病毒受体相关蛋白 4 介导的麻疹病毒在肿瘤中的感染性。
Mol Oncol. 2016 Nov;10(9):1387-1403. doi: 10.1016/j.molonc.2016.07.007. Epub 2016 Jul 28.
3
Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination.用于病毒疗法和疫苗接种的减毒麻疹病毒载体的生物安全考量
Hum Vaccin Immunother. 2016 May 3;12(5):1102-16. doi: 10.1080/21645515.2015.1122146. Epub 2015 Dec 2.
4
The use of the NIS reporter gene for optimizing oncolytic virotherapy.利用NIS报告基因优化溶瘤病毒疗法。
Expert Opin Biol Ther. 2016;16(1):15-32. doi: 10.1517/14712598.2016.1100162. Epub 2015 Oct 12.
5
Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy.抑制极光激酶A可增强溶瘤麻疹病毒疗法的抗肿瘤疗效。
Cancer Gene Ther. 2015 Sep;22(9):438-44. doi: 10.1038/cgt.2015.36. Epub 2015 Aug 14.
6
Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer.表达碘化钠同向转运体的溶瘤麻疹病毒用于治疗耐药性卵巢癌。
Cancer Res. 2015 Jan 1;75(1):22-30. doi: 10.1158/0008-5472.CAN-14-2533. Epub 2014 Nov 14.
7
Measles vaccine strains for virotherapy of non-small-cell lung carcinoma.用于非小细胞肺癌病毒治疗的麻疹疫苗株。
J Thorac Oncol. 2014 Aug;9(8):1101-10. doi: 10.1097/JTO.0000000000000214.
8
Remission of disseminated cancer after systemic oncolytic virotherapy.全身溶瘤病毒治疗后播散性癌症的缓解
Mayo Clin Proc. 2014 Jul;89(7):926-33. doi: 10.1016/j.mayocp.2014.04.003. Epub 2014 May 14.
9
Inhibition of Rho-associated coiled-coil-forming kinase increases efficacy of measles virotherapy.抑制 Rho 相关卷曲螺旋形成激酶可提高麻疹病毒疗法的疗效。
Cancer Gene Ther. 2013 Nov;20(11):630-7. doi: 10.1038/cgt.2013.58. Epub 2013 Oct 25.
10
Immune system: a double-edged sword in cancer.免疫系统：癌症的双刃剑。
Inflamm Res. 2013 Sep;62(9):823-34. doi: 10.1007/s00011-013-0645-9. Epub 2013 Jul 19.
Zotero 插件