Zhang Jie, Liu Kepu, Zhu Zheng, Shang Shihao, Wei Di, Zheng Yu, Zhang Lei, Liang Ying, Ju Dongen, Yuan Jianlin
College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Front Oncol. 2024 Oct 11;14:1461324. doi: 10.3389/fonc.2024.1461324. eCollection 2024.
Urinary tumors pose a significant health threat because of their high prevalence and recurrence rates. Despite the availability of various treatment options, many patients poorly respond to traditional therapies, highlighting the urgent need for alternative approaches. Oncolytic viruses are promising therapeutic agents. These viruses exploit the unique characteristics of cancer cells to specifically target and destroy them, thereby triggering potent antitumor immune responses. This review delves into recent advancements and future prospects of oncolytic viruses, focusing on their application in renal, bladder, and prostate cancers. By discussing practical implications and the potential of different viruses, including the cowpox virus, adenovirus, measles virus, coxsackievirus, and reovirus, we pave the way for further exploration and refinement of this exciting field.
泌尿系统肿瘤因其高发病率和复发率对健康构成重大威胁。尽管有多种治疗选择，但许多患者对传统疗法反应不佳，这凸显了对替代方法的迫切需求。溶瘤病毒是很有前景的治疗剂。这些病毒利用癌细胞的独特特性来特异性地靶向并摧毁它们，从而引发强大的抗肿瘤免疫反应。本综述深入探讨溶瘤病毒的最新进展和未来前景，重点关注它们在肾癌、膀胱癌和前列腺癌中的应用。通过讨论不同病毒（包括牛痘病毒、腺病毒、麻疹病毒、柯萨奇病毒和呼肠孤病毒）的实际意义和潜力，我们为进一步探索和完善这一令人兴奋的领域铺平了道路。
