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开发针对……的有效疫苗：关键考量与挑战

Developing a potent vaccine against : critical considerations and challenges.

作者信息

Hasanzadeh Haghighi Faria, Menbari Shaho, Mohammadzadeh Roghayeh, Pishdadian Abbas, Farsiani Hadi

机构信息

Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.

出版信息

Expert Rev Mol Med. 2024 Nov 25;27:e12. doi: 10.1017/erm.2024.19.

DOI:10.1017/erm.2024.19
PMID:39584502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11964096/
Abstract

( is closely associated with gastric cancer and peptic ulcers. The effectiveness of antibiotic treatment against is diminished by the emergence of drug-resistant strains, side effects, high cost and reinfections. Given the circumstances, it is imperative to develop a potent vaccination targeting Understanding 's pathogenicity and the host's immune response is essential to developing a vaccine. Furthermore, vaccine evaluation necessitates the careful selection of design formulation. This review article aims to provide a concise overview of the considerations involved in selecting the optimal antigen, adjuvant, vaccine delivery system and laboratory animal model for vaccine formulation. Furthermore, we will discuss some significant obstacles in the realm of developing a potent vaccination against

摘要

（与胃癌和消化性溃疡密切相关。抗生素治疗针对……的有效性因耐药菌株的出现、副作用、高成本和再感染而降低。在这种情况下，开发一种针对……的有效疫苗势在必行。了解……的致病性和宿主的免疫反应对于开发疫苗至关重要。此外，疫苗评估需要仔细选择设计配方。这篇综述文章旨在简要概述在为疫苗配方选择最佳抗原、佐剂、疫苗递送系统和实验动物模型时所涉及的考虑因素。此外，我们将讨论在开发针对……的有效疫苗领域中的一些重大障碍。 ）

注：原文中部分内容不完整，用“……”表示了缺失部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/2ca0a0069e6c/S146239942400019X_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/4e98ce1be6dc/S146239942400019X_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/110494815683/S146239942400019X_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/2ca0a0069e6c/S146239942400019X_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/4e98ce1be6dc/S146239942400019X_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/110494815683/S146239942400019X_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39b1/11964096/2ca0a0069e6c/S146239942400019X_fig3.jpg

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[1]
Developing a potent vaccine against : critical considerations and challenges.

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引用本文的文献

[1]
Unraveling : Insights into Pathogenesis, Immune Evasion, and Progress Toward Effective Vaccination.

Vaccines (Basel). 2025-7-3

[2]
Advances in Helicobacter pylori lipopolysaccharide structure and function.

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[3]
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[4]
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[5]
Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.

Gut Pathog. 2025-5-23

[6]
Decoding the Ability of Helicobacter pylori to Evade Immune Recognition and Cause Disease.

Cell Mol Gastroenterol Hepatol. 2025

本文引用的文献

[1]
An Evaluation of Urease A Subunit Nanocapsules as a Vaccine in a Mouse Model of Infection.

Vaccines (Basel). 2023-10-27

[2]
Advances in Helicobacter pylori vaccine research: From candidate antigens to adjuvants-A review.

Helicobacter. 2024

[3]
Vaccination therapy for inflammatory bowel disease.

Hum Vaccin Immunother. 2023-8

[4]
Helicobacter pylori strains isolated from raw poultry meat: frequency and molecular characteristics.

Sci Rep. 2023-7-10

[5]
How Long Will It Take to Launch an Effective Vaccine for Humans?

Infect Drug Resist. 2023-6-15

[6]
Recombinant lactic acid bacteria as promising vectors for mucosal vaccination.

Exploration (Beijing). 2021-10-30

[7]
and Its Role in Gastric Cancer.

Microorganisms. 2023-5-17

[8]
Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines.

Helicobacter. 2023-8

[9]
virulence factors: subversion of host immune system and development of various clinical outcomes.

Expert Rev Mol Med. 2023-6-13

[10]
Strains Isolated from Raw Poultry Meat in the Shahrekord Region, Iran: Frequency and Molecular Characteristics.

Genes (Basel). 2023-4-28

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