Ali-Hassan-Al-Saegh Sadeq, Mirhosseini Seyed Jalil, Karimi-Bondarabadi Ali Akbar, Sahidzadeh Azadeh, Mahdavi Parisa, Tahernejad Mahbube, Heydari Safieyehsadat, Weymann Alexander, Zeriouh Mohamed, Sabashnikov Anton, Popov Aron-Frederik
Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Indian Heart J. 2017 Jan-Feb;69(1):112-118. doi: 10.1016/j.ihj.2016.08.001. Epub 2016 Aug 25.
This systematic review with meta-analysis sought to determine the efficacy, safety of implantation of cardiac resynchronization therapy (CRT) in mild heart failure (HF). Medline, Embase, Elsevier, and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The literature search of all major databases retrieved 2035 studies. After screening, a total of 10 trials were identified that reported outcomes of interest. Pooled analysis was performed on left ventricular (LV) ejection fraction (P<0.001), LV end-diastolic volume (P<0.001), LV end-systolic volume (P<0.001), LV end-diastolic diameter (P<0.001), LV end-systolic diameter (P<0.001), incidence of progression of heart failure (P<0.001), mortality (P=0.06), infection (P=0.1), and pneumothorax (P=0.08). Overall, implantation of CRT in patients with asymptomatic and mild HF resulted in improved cardiac function, decreased progression of HF, trend to decrease of mortality in short to long-term follow-up.
这项荟萃分析系统评价旨在确定心脏再同步治疗（CRT）植入术在轻度心力衰竭（HF）中的疗效和安全性。使用Medline、Embase、爱思唯尔和科学在线数据库以及谷歌学术文献来选择采用随机对照设计的合适研究。对所有主要数据库进行文献检索共获得2035项研究。经过筛选，共确定了10项报告了感兴趣结局的试验。对左心室（LV）射血分数（P<0.001）、左心室舒张末期容积（P<0.001）、左心室收缩末期容积（P<0.001）、左心室舒张末期直径（P<0.001）、左心室收缩末期直径（P<0.001）、心力衰竭进展发生率（P<0.001）、死亡率（P=0.06）、感染（P=0.1）和气胸（P=0.08）进行了汇总分析。总体而言，在无症状和轻度HF患者中植入CRT可改善心功能，降低HF进展，在短期至长期随访中有降低死亡率的趋势。
