Shahriyari Leili
Mathematical Biosciences Institute, The Ohio State University, Columbus, OH 43210, USA
J R Soc Interface. 2017 Feb;14(127). doi: 10.1098/rsif.2016.0977.
Most cancer treatments cause necrotic cell deaths in the tumour microenvironment. Necrotic cells send signals to immune cells to start the wound healing process in the tissue. Therefore, we assume after stopping treatments there is a wound that needs to be healed. We develop a simple computational model to investigate cell dynamics during the wound healing process after treatments. The model predicts that the involvement of high-fitness cancer cells in the wound healing leads to fast relapse, and cancer cells outside of the wound can cause a slow recurrence of the tumour. Therefore, the absence of relapse after treatments may imply a slow-developing tumour that might not reach an observable size in the patients' lifetime. Additionally, the model indicates that the location of remaining cancer cells after treatments is an important factor in the recurrence time. The fastest recurrence happens when high-fitness cancer cells remain inside of the wound. However, the longest time to recurrence corresponds to cancer cells located outside of the wound. Note that this model is the first attempt to study cell dynamics in the wound healing process after cancer treatments, and it has some limitations that might influence the results. Experiments are needed to validate the results.
大多数癌症治疗会在肿瘤微环境中导致坏死性细胞死亡。坏死细胞向免疫细胞发送信号，以启动组织中的伤口愈合过程。因此，我们假设在停止治疗后存在一个需要愈合的伤口。我们开发了一个简单的计算模型来研究治疗后伤口愈合过程中的细胞动态。该模型预测，高适应性癌细胞参与伤口愈合会导致快速复发，而伤口外的癌细胞会导致肿瘤缓慢复发。因此，治疗后无复发可能意味着肿瘤发展缓慢，在患者的生命周期内可能不会达到可观察到的大小。此外，该模型表明，治疗后残留癌细胞的位置是复发时间的一个重要因素。当高适应性癌细胞留在伤口内时，复发最快。然而，最长的复发时间对应于位于伤口外的癌细胞。请注意，该模型是首次尝试研究癌症治疗后伤口愈合过程中的细胞动态，并且它有一些可能影响结果的局限性。需要进行实验来验证结果。
