婴儿喂养方式是否会调节乳糜泻和1型糖尿病的表现？
Does infant feeding modulate the manifestation of celiac disease and type 1 diabetes?
作者信息
Meijer Caroline R, Discepolo Valentina, Troncone Riccardo, Mearin Maria L
机构信息
aDepartment of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands bDepartment of Translation Medical Science, Section of Pediatric and European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Naples, Italy.
出版信息
Curr Opin Clin Nutr Metab Care. 2017 May;20(3):222-226. doi: 10.1097/MCO.0000000000000367.
PURPOSE OF REVIEW
The review aims to critically discuss the role of infant feeding in the development of celiac disease and type 1 diabetes (T1D).
RECENT FINDINGS
Prospective observational and randomized interventional studies show that breastfeeding (BF) or BF during gluten introduction does not reduce the risk of developing CD, but high gluten consumption before age 2 years increased the risk in Swedish children.Despite evidence from retrospective studies, prospective trials failed to find a protective effect of breastfeeding against the risk of T1D development. Nevertheless, breastfeeding at the time of cereal introduction decreases this risk. There is some evidence demonstrating that early exposure to sugar-sweetened beverages increases the risk of T1D in childhood, whereas the timing of gluten introduction, except if introduced very early, does not affect it.
SUMMARY
Breastfeeding and/or timing of gluten introduction does not influence celiac disease risk. Breastfeeding at the time of cereal introduction might be protective against T1D. The introduction of certain solid foods at an early age may be associated with the risk of T1D.
综述目的
本综述旨在批判性地讨论婴儿喂养在乳糜泻和1型糖尿病（T1D）发病中的作用。
最新研究发现
前瞻性观察性研究和随机干预性研究表明，母乳喂养（BF）或在引入麸质期间进行母乳喂养并不能降低患乳糜泻的风险，但2岁前高麸质摄入量会增加瑞典儿童患该病的风险。尽管回顾性研究有相关证据，但前瞻性试验未能发现母乳喂养对预防T1D发病有保护作用。然而，在引入谷物时进行母乳喂养可降低这种风险。有一些证据表明，儿童早期接触含糖饮料会增加患T1D的风险，而麸质引入的时间，除非很早引入，否则不会影响患病风险。
总结
母乳喂养和/或麸质引入时间不影响乳糜泻风险。在引入谷物时进行母乳喂养可能对T1D有预防作用。早期引入某些固体食物可能与T1D风险有关。
Zotero 插件