Albin R L, Albers J W, Greenberg H S, Townsend J B, Lynn R B, Burke J M, Alessi A G
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109-0032.
Neurology. 1987 Nov;37(11):1729-32. doi: 10.1212/wnl.37.11.1729.
We report two patients who developed an acute, profound, and permanent sensory deficit after treatment with massive doses of parenteral pyridoxine. Aside from rapid onset, their clinical picture resembles that described in chronic pyridoxine neurotoxicity. It also is consonant with experimental models of acute pyridoxine intoxication and is probably secondary to a sensory ganglion neuronopathy. These patients also had transient autonomic dysfunction, mild weakness, nystagmus, lethargy, and respiratory depression. These previously undocumented features may be attributable to either the preservative used in the parenteral pyridoxine preparation or to the exceptionally high doses of pyridoxine these patients received.
我们报告了两名患者，他们在接受大剂量胃肠外吡哆醇治疗后出现了急性、严重且永久性的感觉缺陷。除了起病迅速外，他们的临床表现与慢性吡哆醇神经毒性中所描述的相似。这也与急性吡哆醇中毒的实验模型一致，并且可能继发于感觉神经节神经元病。这些患者还出现了短暂的自主神经功能障碍、轻度无力、眼球震颤、嗜睡和呼吸抑制。这些先前未被记录的特征可能归因于胃肠外吡哆醇制剂中使用的防腐剂，或者归因于这些患者接受的极高剂量的吡哆醇。
