Cryolumpectomy for carcinoma of the breast.

Cryosurgery and surgical en bloc excision in preventing the local recurrence of mammary adenocarcinoma were studied in BALB/cfC3H (supplied by the Cancer Research Institute, University of California Berkeley) syngeneic mice carrying virus induced mammary adenocarcinomas transplanted into the fourth mammary fat pad. Cryosurgical procedures involving multiple freeze-thaw cycles to minus 180 degrees C. followed by tumor excision substantially reduced the local recurrence rate of carcinoma of the mammary gland in the mouse. The use of cryolumpectomy in the treatment of early carcinoma of the breast in humans is presented herein.