Rand R W, Rand R P, Eggerding F A, Field M, Denbesten L, King W, Camici S
Cryobiology. 1985 Aug;22(4):307-18. doi: 10.1016/0011-2240(85)90178-6.
The effects of cryosurgical procedures and surgical excision in preventing the local recurrence of mammary adenocarcinoma were studied in BALB/cfC3H mice carrying syngeneic, virus-induced mammary adenocarcinomas transplanted into the fourth mammary fat pad. In this report we present evidence demonstrating that cryosurgical procedures involving multiple freeze-thaw cycles followed by tumor excision markedly reduce the local recurrence rate of mouse mammary cancer. Surgical resection without cryotreatment resulted in an 80% local recurrence rate; in contrast, cryotreatment consisting of three freeze-thaw cycles before excision prevented local tumor recurrence in 70% of the animals. The use of cryotherapy and local excision (cryolumpectomy) in the treatment of human breast cancer is discussed.
在将同基因、病毒诱导的乳腺腺癌移植到第四乳腺脂肪垫的BALB/cfC3H小鼠中，研究了冷冻手术程序和手术切除在预防乳腺腺癌局部复发方面的效果。在本报告中，我们提供的证据表明，经过多次冻融循环然后切除肿瘤的冷冻手术程序可显著降低小鼠乳腺癌的局部复发率。未经冷冻处理的手术切除导致局部复发率为80%；相比之下，在切除前进行三个冻融循环的冷冻处理可使70%的动物避免局部肿瘤复发。本文还讨论了冷冻疗法和局部切除（冷冻肿块切除术）在治疗人类乳腺癌中的应用。
