Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
ACS Nano. 2017 Mar 28;11(3):3247-3253. doi: 10.1021/acsnano.7b00352. Epub 2017 Mar 3.
Cu-functionalized carbon nitride nanoparticles (Cu-g-CN NPs), ∼200 nm, and Cu-carbon dots (Cu-C-dots), ∼8 nm, act as horseradish peroxidase-mimicking catalysts. The nanoparticles catalyze the generation of chemiluminescence in the presence of luminol/HO and catalyze the oxidation of dopamine by HO to form aminochrome. The Cu-g-CN-driven generation of chemiluminescence is used to develop a HO sensor and is implemented to develop a glucose detection platform and a sensor for probing glucose oxidase. Also, the Cu-C-dots are functionalized with the β-cyclodextrin (β-CD) receptor units. The concentration of dopamine, at the Cu-C-dots' surface, by means of the β-CD receptor sites, leads to a 4-fold enhancement in the oxidation of dopamine by HO to yield aminochrome compared to that of the unmodified C-dots.
Cu 功能化氮化碳纳米颗粒（Cu-g-CN NPs），约 200nm，和 Cu 碳点（Cu-C-dots），约 8nm，作为辣根过氧化物酶模拟催化剂。纳米颗粒在存在鲁米诺/HO 的情况下催化化学发光的产生，并催化 HO 对多巴胺的氧化以形成氨基查尔酮。Cu-g-CN 驱动的化学发光的产生用于开发 HO 传感器，并用于开发葡萄糖检测平台和用于探测葡萄糖氧化酶的传感器。此外，Cu-C-dots 被 β-环糊精（β-CD）受体单元功能化。通过 β-CD 受体位点，在 Cu-C-dots 表面处多巴胺的浓度导致 HO 对多巴胺的氧化生成氨基查尔酮的速率相对于未修饰的 C-dots 提高了 4 倍。
