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一场抢座位游戏：DNA损伤后，促进和反对切除的因子竞争与TOPBP1结合。

A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage.

作者信息

Shimada Kenji, Gasser Susan M

机构信息

Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland

Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.

出版信息

J Cell Biol. 2017 Mar 6;216(3):535-537. doi: 10.1083/jcb.201701038. Epub 2017 Feb 24.

DOI:10.1083/jcb.201701038
PMID:28235945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5350523/
Abstract

DNA double strand breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination. In this issue, Liu et al. (2017. https://doi.org/10.1083/jcb.201607031) report that the conserved scaffold protein TOPBP1 provides binding sites for both pro- and anti-resection factors at DSBs, providing insights into repair pathway regulation.

摘要

DNA双链断裂（DSBs）通常通过非同源末端连接或同源重组进行修复。在本期中，刘等人（2017年。https://doi.org/10.1083/jcb.201607031）报告称，保守的支架蛋白TOPBP1在DSBs处为促进和抗切除因子提供结合位点，这为修复途径调控提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4d/5350523/30ccfbd53cfb/JCB_201701038_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4d/5350523/30ccfbd53cfb/JCB_201701038_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4d/5350523/30ccfbd53cfb/JCB_201701038_Fig1.jpg

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本文引用的文献

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J Cell Biol. 2017 Mar 6;216(3):623-639. doi: 10.1083/jcb.201607031. Epub 2017 Feb 22.
2
Coupling of Homologous Recombination and the Checkpoint by ATR.ATR介导的同源重组与细胞周期检查点的偶联
Mol Cell. 2017 Jan 19;65(2):336-346. doi: 10.1016/j.molcel.2016.12.007. Epub 2017 Jan 12.
3
BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation.
BRCA1 通过促进 53BP1 去磷酸化来引导修复途径走向同源重组。
Cell Rep. 2017 Jan 10;18(2):520-532. doi: 10.1016/j.celrep.2016.12.042.
4
The control of DNA repair by the cell cycle.细胞周期对 DNA 修复的调控。
Nat Cell Biol. 2016 Dec 23;19(1):1-9. doi: 10.1038/ncb3452.
5
53BP1 fosters fidelity of homology-directed DNA repair.53BP1 促进同源定向 DNA 修复的保真度。
Nat Struct Mol Biol. 2016 Aug;23(8):714-21. doi: 10.1038/nsmb.3251. Epub 2016 Jun 27.
6
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.H4K20me0标记复制后染色质并招募TONSL–MMS22L DNA修复复合物。
Nature. 2016 Jun 30;534(7609):714-718. doi: 10.1038/nature18312. Epub 2016 Jun 22.
7
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Slx4和Rtt107控制双链断裂处的检查点信号传导和DNA切除。
Nucleic Acids Res. 2016 Jan 29;44(2):669-82. doi: 10.1093/nar/gkv1080. Epub 2015 Oct 20.
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