膜相关鸟苷酸激酶（MAGUKs）：多面突触组织者。
MAGUKs: multifaceted synaptic organizers.
作者信息
Won Sehoon, Levy Jon M, Nicoll Roger A, Roche Katherine W
机构信息
Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States.
出版信息
Curr Opin Neurobiol. 2017 Apr;43:94-101. doi: 10.1016/j.conb.2017.01.006. Epub 2017 Feb 23.
Abstract
The PSD-95 family of proteins, known as MAGUKs, have long been recognized to be central building blocks of the PSD. They are categorized as scaffolding proteins, which link surface-expressed receptors to the intracellular signaling molecules. Although the four members of the PSD-95 family (PSD-95, PSD-93, SAP102, and SAP97) have many shared roles in regulating synaptic function, recent studies have begun to delineate specific binding partners and roles in plasticity. In the current review, we will highlight the conserved and unique roles of these proteins.
摘要
被称为膜相关鸟苷酸激酶（MAGUKs）的PSD-95蛋白家族，长期以来一直被认为是突触后致密区（PSD）的核心组成部分。它们被归类为支架蛋白，可将表面表达的受体与细胞内信号分子连接起来。尽管PSD-95家族的四个成员（PSD-95、PSD-93、SAP102和SAP97）在调节突触功能方面有许多共同作用，但最近的研究已开始明确它们在可塑性方面的特定结合伴侣和作用。在本综述中，我们将重点介绍这些蛋白的保守和独特作用。
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