Hishida M
Shika Rikogaku Zasshi. 1977 Oct;18(44):254-69.
The effects of beryllium addition to a dental cobalt-chromium alloy on biological compatibility as well as physical properties were examined and the following results were obtained. 1. Slight, but significant depression of the rates of cell multiplication was obtained with the experimental groups, i.e., alloy with no beryllium added as well as alloys with beryllium of up to 3.0 per cent by weight, compared to control group, which contained no alloys, but a glass disk. Within the experimental groups no significant difference in the rates of cell multiplication was found between the alloys with beryllium addition ranging from zero up to 2.0% by weight. However, alloy with 3.0% beryllium yielded slight, but significant depression of the rates of cell multiplication. Pure beryllium metal revealed severe cytotoxicity. 2. Cell morphology of the experimental groups confirmed the above results of the rate of cell multiplication. 3. Increase of beryllium within the alloys resulted in increase of tensile strength as well as Rockwell hardness, while elongation and fusion temperature were brought down. 4. Metallographs of alloys and cast specimens confirmed the results of the mechanical properties. The more beryllium was added, the smaller was the alloy crystal observed. 5. Loss of beryllium in the alloy was found during such procedures as melting each metal for making up alloys and casting. It is considered that the present results will be able to lend suggestions to beryllium use in dentistry with regard to biological compatibility as well as physical properties.
研究了向牙科钴铬合金中添加铍对生物相容性以及物理性能的影响，并得到了以下结果。1. 与不含合金但含有玻璃盘的对照组相比，实验组（即未添加铍的合金以及铍含量高达3.0%（重量）的合金）的细胞增殖速率略有但显著降低。在实验组中，铍添加量从零到2.0%（重量）的合金之间，细胞增殖速率未发现显著差异。然而，含3.0%铍的合金导致细胞增殖速率略有但显著降低。纯铍金属显示出严重的细胞毒性。2. 实验组的细胞形态证实了上述细胞增殖速率的结果。3. 合金中铍含量的增加导致抗拉强度和洛氏硬度增加，而伸长率和熔化温度降低。4. 合金和铸造试样的金相照片证实了力学性能的结果。添加的铍越多，观察到的合金晶体越小。5. 在制备合金和铸造时熔化每种金属的过程中，发现合金中的铍会损失。认为目前的结果将能够就铍在牙科中的生物相容性和物理性能方面的使用提供建议。
