Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, University of Melbourne, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Australia.
Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, University of Melbourne, Australia.
Psychiatry Res. 2017 Jun;252:16-22. doi: 10.1016/j.psychres.2017.02.023. Epub 2017 Feb 11.
Depressive pathology is common in first-episode schizophrenia spectrum disorders (FES), and is frequently assessed using the Center for Epidemiological Studies - Depression Scale (CES-D), an instrument designed for use in community samples. Despite its widespread use, no prior study has examined the psychometric validity of the CES-D in assessing depressive pathology in FES. The aim of this study was to examine the psychometric validity of the CES-D in FES. This study involved secondary analysis of baseline data from a single blind, randomized controlled trial of vocational intervention for individuals with FES (N=91; age range: 15-25 years). Measures used were: CES-D, Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Structured Clinical Interview for DSM-IV-TR (SCID-I/P). The CES-D strongly correlated with the depression subscale of the BPRS, and with the presence of full-threshold depressive disorder on the SCID-I/P. There was minimal overlap between the CES-D and SANS, with weak correlations emerging for avolition and anhedonia, and not for affective flattening, alogia, and attention. The CES-D cut-off of ≥23 produced high sensitivity and specificity values for determining full-threshold comorbid depressive disorder. Such findings indicate that the CES-D is effective for assessing and measuring depressive pathology in FES.
抑郁病理学在首发精神分裂症谱系障碍（FES）中很常见，通常使用专为社区样本设计的流行病学研究中心抑郁量表（CES-D）进行评估。尽管它被广泛使用，但之前没有研究检查 CES-D 在评估 FES 中抑郁病理学方面的心理测量效度。本研究旨在研究 CES-D 在 FES 中的心理测量效度。本研究涉及对 FES 个体职业干预的单盲、随机对照试验的基线数据的二次分析（N=91；年龄范围：15-25 岁）。使用的测量方法是：CES-D、简明精神病评定量表（BPRS）、阴性症状评定量表（SANS）和 DSM-IV-TR 结构临床访谈（SCID-I/P）。CES-D 与 BPRS 的抑郁分量表以及 SCID-I/P 上全阈值抑郁障碍的存在呈强烈相关。CES-D 与 SANS 之间几乎没有重叠，出现了意志减退和快感缺失的弱相关，而不是情感迟钝、寡言和注意力不集中。CES-D 切点≥23 可有效确定全阈值共患抑郁障碍。这些发现表明，CES-D 可有效评估和测量 FES 中的抑郁病理学。
