Sanchis Yovana, Yusà Vicent, Coscollà Clara
Foundation for the Promotion of the Health and Biomedical Research in the Valencia Region (FISABIO-Public Health), 21, Avenida Catalunya, 46020 Valencia, Spain; Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain.
Foundation for the Promotion of the Health and Biomedical Research in the Valencia Region (FISABIO-Public Health), 21, Avenida Catalunya, 46020 Valencia, Spain; Public Health Laboratory of Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain; Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100 Burjassot, Spain.
J Chromatogr A. 2017 Mar 24;1490:22-46. doi: 10.1016/j.chroma.2017.01.076. Epub 2017 Feb 1.
In this review, we present current approaches in the analysis of food-packaging contaminants. Gas and liquid chromatography coupled to mass spectrometry detection have been widely used in the analysis of some relevant families of these compounds such as primary aromatic amines, bisphenol A, bisphenol A diglycidyl ether and related compounds, UV-ink photoinitiators, perfluorinated compounds, phthalates and non-intentionally added substances. Main applications for sample treatment and different types of food-contact material migration studies have been also discussed. Pressurized Liquid Extraction, Solid-Phase Microextraction, Focused Ultrasound Solid-Liquid Extraction and Quechers have been mainly used in the extraction of food contact material (FCM) contaminants, due to the trend of minimising solvent consumption, automatization of sample preparation and integration of extraction and clean-up steps. Recent advances in analytical methodologies have allowed unequivocal identification and confirmation of these contaminants using Liquid Chromatography coupled to High Resolution Mass Spectrometry (LC-HRMS) through mass accuracy and isotopic pattern applying. LC-HRMS has been used in the target analysis of primary aromatic amines in different plastic materials, but few studies have been carried out applying this technique in post-target and non-target analysis of FCM contaminants.
在本综述中，我们介绍了食品包装污染物分析的当前方法。气相色谱和液相色谱与质谱检测联用已广泛用于分析这些化合物的一些相关类别，如伯芳香胺、双酚A、双酚A二缩水甘油醚及相关化合物、紫外油墨光引发剂、全氟化合物、邻苯二甲酸盐和非有意添加物质。还讨论了样品处理的主要应用以及不同类型的食品接触材料迁移研究。由于有尽量减少溶剂消耗、实现样品制备自动化以及整合萃取和净化步骤的趋势，加压液体萃取、固相微萃取、聚焦超声固液萃取和快速、简便、廉价、有效、耐用、安全（QuEChERS）方法主要用于萃取食品接触材料（FCM）污染物。分析方法的最新进展使得通过应用质量精度和同位素模式，利用液相色谱与高分辨率质谱联用（LC-HRMS）明确鉴定和确认这些污染物成为可能。LC-HRMS已用于不同塑料材料中伯芳香胺的目标分析，但在FCM污染物的目标后分析和非目标分析中应用该技术的研究很少。
