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商业啤酒：邻苯二甲酸盐和己二酸二（2-乙基己基）酯的一个来源。

Commercial beers: A source of phthalates and di-ethylhexyl adipate.

作者信息

Pereira Cheila, Cunha Sara C, Fernandes José O

机构信息

LAQV-REQUIMTE, Laboratory of Bromatology e Hidrology, Facultaty of Pharmacy, University of Porto, Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.

出版信息

Food Chem X. 2023 Jun 24;19:100768. doi: 10.1016/j.fochx.2023.100768. eCollection 2023 Oct 30.

DOI:10.1016/j.fochx.2023.100768
PMID:37780332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10534124/
Abstract

Beer is one of the most consumed beverages worldwide. Different materials used along its production and packaging can result in human exposure to phthalates and adipates. The aim of this study was to assess simultaneously the levels of phthalates and di-ethylhexyl adipate (DEHA) in commercial beer samples (n = 66) with a method based on DLLME and detection with GC-MS/MS, and further evaluate human exposure. Six out of seven compounds studied were found in the beers analysed, with levels ranging from 1.77 to 205.40 µg/L. The most prevalent was DEHA at 205.40 µg/L, while dimethyl phthalate (DMP) was not present in any sample. Samples with 5-6 % alcohol, packed in aluminium cans and produced in an industrial environment presented the highest level of these contaminants. Despite low-risk exposure to phthalates and adipate with beer, it is important to remember the ubiquitous nature of these compounds, which can lead to cumulative exposure.

摘要

啤酒是全球消费最多的饮品之一。其生产和包装过程中使用的不同材料可能导致人体接触邻苯二甲酸盐和己二酸酯。本研究的目的是采用基于分散液液微萃取（DLLME）和气相色谱-串联质谱（GC-MS/MS）检测的方法，同时评估市售啤酒样品（n = 66）中邻苯二甲酸盐和己二酸二（2-乙基己基）酯（DEHA）的含量，并进一步评估人体暴露情况。在所分析的啤酒中，研究的七种化合物中有六种被检出，含量范围为1.77至205.40 μg/L。最普遍的是含量为205.40 μg/L的DEHA，而邻苯二甲酸二甲酯（DMP）在任何样品中均未检出。酒精含量为5-6%、采用铝罐包装且在工业环境中生产的样品中，这些污染物的含量最高。尽管通过啤酒接触邻苯二甲酸盐和己二酸酯的风险较低，但重要的是要记住这些化合物无处不在的特性，这可能导致累积暴露。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/b736418d1b3e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/5f236742ae29/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/65cebc9d0d09/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/4456d0fda957/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/b736418d1b3e/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/5f236742ae29/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/65cebc9d0d09/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/4456d0fda957/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/779e/10534124/b736418d1b3e/gr4.jpg

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Commercial beers: A source of phthalates and di-ethylhexyl adipate.

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引用本文的文献

[1]
Migration of Phthalates and Bisphenol A from Polyethylene Terephthalate Bottles into Beer During Storage at Controlled Temperatures.

Foods. 2025-7-30

[2]
Applications of Microextraction Technology for the Analysis of Alcoholic Beverages Quality: Current Perspectives and Future Directions.

Foods. 2025-3-26

[3]
Unveiling the effects of micro and nano plastics in embryonic development.

Toxicol Rep. 2025-2-19

[4]
Micro(nano)plastic and Related Chemicals: Emerging Contaminants in Environment, Food and Health Impacts.

Toxics. 2024-10-20

[5]
Understanding How Chemical Pollutants Arise and Evolve in the Brewing Supply Chain: A Scoping Review.

Foods. 2024-5-29

本文引用的文献

[1]
Phthalic acid esters and adipates in herbal-based soft drinks: an eco-friendly method.

Anal Bioanal Chem. 2021-5

[2]
Di(2-ethylhexyl) adipate plasticizer triggers hepatic, brain, and cardiac injury in rats: Mitigating effect of Peganum harmala oil.

Ecotoxicol Environ Saf. 2021-1-15

[3]
Factors influencing the choice of beer: A review.

Food Res Int. 2020-11

[4]
Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact.

Int J Environ Res Public Health. 2020-8-5

[5]
Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials.

EFSA J. 2019-12-11

[6]
A simple, fast and easy methodology for the monitoring of plastic migrants in alcoholic and non-alcoholic beverages using the QuEChERS method prior to gas chromatography tandem mass spectrometry.

Anal Bioanal Chem. 2020-1-17

[7]
An electrodeposited terephthalic acid-layered double hydroxide (Cu-Cr) nanosheet coating for in-tube solid-phase microextraction of phthalate esters.

Mikrochim Acta. 2020-1-10

[8]
A Review of Biomonitoring of Phthalate Exposures.

Toxics. 2019-4-5

[9]
Phthalates impact human health: Epidemiological evidences and plausible mechanism of action.

J Hazard Mater. 2017-6-19

[10]
Analytical strategies for organic food packaging contaminants.

J Chromatogr A. 2017-3-24

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