KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
作者信息
Johansson Elisabet, Biagini Myers Jocelyn M, Martin Lisa J, He Hua, Pilipenko Valentina, Mersha Tesfaye, Weirauch Matthew, Salomonis Nathan, Ryan Patrick, LeMasters Grace K, Bernstein David I, Lockey James, Khurana Hershey Gurjit K
机构信息
Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
出版信息
J Allergy Clin Immunol. 2017 Aug;140(2):595-598.e5. doi: 10.1016/j.jaci.2017.02.003. Epub 2017 Feb 24.
Abstract
摘要
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Meta-analysis identifies seven susceptibility loci involved in the atopic march.荟萃分析确定了七个与特应性进程相关的易感基因座。
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Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.全基因组关联研究在日本人群中鉴定出特应性皮炎的 8 个新易感位点。
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The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research.大辛辛那提儿科诊所资料库：儿童哮喘与过敏研究的新框架
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Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohort.湿疹、哮喘和鼻炎的发展和共病至 12 岁：来自 BAMSE 出生队列的研究数据。
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.全基因组关联研究的荟萃分析确定了特应性皮炎的三个新风险位点。
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Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.利用 RNA 表达和群体等位基因频率差异鉴定 KIF3A 为儿童哮喘的新候选基因。
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Spurious genetic associations.虚假的基因关联。
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J Pediatr. 2006 Oct;149(4):505-11. doi: 10.1016/j.jpeds.2006.06.035.
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Evaluating coverage of genome-wide association studies.评估全基因组关联研究的覆盖范围。
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