Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China; Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, sanya 572014, PR China; Chinese PLA General Hospital Hainan branch, 9 Haitang Bay, Sanya 572014, PR China.
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, PR China.
Ageing Res Rev. 2017 Jul;36:32-41. doi: 10.1016/j.arr.2017.02.005. Epub 2017 Feb 24.
Cutaneous wounding in late-gestational fetal or postnatal humans results in scar formation without any skin appendages. Early or mid- gestational skin healing in humans is characterized by the absence of scaring in a process resembling regeneration. Tremendous cellular and molecular mechanisms contribute to this distinction, and fibroblasts play critical roles in scar or scarless wound healing. This review discussed the different repair mechanisms involved in wound healing of fibroblasts at different developmental stages and further confirmed that fetal fibroblast transplantation resulted in reduced scar healing in vivo. We also discussed the possible problem in fetal fibroblast transplantation for wound repair. We proposed the use of small molecules to improve the regenerative potential of repairing cells in the wound given that remodeling of the wound microenvironment into a regenerative microenvironment in adults might improve skin regeneration.
晚期胎儿或新生儿皮肤创伤会导致无皮肤附属物的瘢痕形成。人类早期或中期的皮肤愈合过程以无瘢痕的再生方式为特征。大量的细胞和分子机制促成了这种区别，成纤维细胞在瘢痕或无瘢痕的伤口愈合中起着关键作用。这篇综述讨论了不同发育阶段成纤维细胞参与伤口愈合的不同修复机制，并进一步证实了胎儿成纤维细胞移植可减少体内瘢痕愈合。我们还讨论了胎儿成纤维细胞移植用于伤口修复的可能问题。我们提出使用小分子来提高伤口修复细胞的再生潜力，因为将伤口微环境重塑为再生微环境可能会改善皮肤再生。
