Gruden M A, Davydova T V, Fomina V G, Vetrile L A, Morozova-Roche L A, Sewell R D E
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2017 Feb;162(4):430-432. doi: 10.1007/s10517-017-3632-2. Epub 2017 Feb 27.
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
在老年C57Bl/6小鼠中，慢性鼻内给予促炎S100A9蛋白的纤维状结构会损害被动回避学习能力。在旷场试验中，S100A9纤维与谷氨酸抗体联合治疗后，动物的水平运动活动增加，且未干扰空间记忆。
