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抗谷氨酸抗体可降低老年记忆障碍小鼠脑结构中的白细胞介素 6 含量。

Antibodies to Glutamate Reduce the IL-6 Content in Cerebral Structures in Mice with Age-Related Memory Impairment.

机构信息

Institute of General Pathology and Pathophysiology, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2024 Sep;177(5):607-609. doi: 10.1007/s10517-024-06233-6. Epub 2024 Sep 28.

DOI:10.1007/s10517-024-06233-6
PMID:39342009
Abstract

Intranasal administration of antibodies to glutamate for 14 days improved passive avoidance conditioning and reduces the content of IL-6 within 7 days after their withdrawal in the prefrontal cortex and hippocampus of aging C57BL/6 mice.

摘要

鼻腔内给予谷氨酸抗体 14 天可改善衰老 C57BL/6 小鼠前额叶皮层和海马体的被动回避条件反射，并在停药后 7 天内降低 IL-6 含量。

相似文献

1
Antibodies to Glutamate Reduce the IL-6 Content in Cerebral Structures in Mice with Age-Related Memory Impairment.抗谷氨酸抗体可降低老年记忆障碍小鼠脑结构中的白细胞介素 6 含量。
Bull Exp Biol Med. 2024 Sep;177(5):607-609. doi: 10.1007/s10517-024-06233-6. Epub 2024 Sep 28.
2
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.谷氨酸抗体对C57Bl/6小鼠年龄相关记忆变化的影响。
Bull Exp Biol Med. 2019 Jan;166(3):326-329. doi: 10.1007/s10517-019-04343-0. Epub 2019 Jan 9.
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Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.抗谷氨酸抗体对衰老C57BL/6小鼠的行为和神经化学延迟效应
Bull Exp Biol Med. 2021 May;171(1):19-22. doi: 10.1007/s10517-021-05163-x. Epub 2021 May 28.
4
Effects of Antibodies to Glutamate on Cerebral Expression of the Tnfrsf1A Gene under Conditions of Spatial Amnesia Induced by Proinflammatory Protein S100A9 Fibrils in Aging Mice.在致炎蛋白 S100A9 纤维诱导衰老小鼠空间记忆障碍条件下，谷氨酸抗体对 Tnfrsf1A 基因在大脑中表达的影响。
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Effect of antibodies to glutamate on retention of conditioned passive avoidance response in rats with ischemic injury of the prefrontal cortex.谷氨酸抗体对前额叶皮质缺血性损伤大鼠条件性被动回避反应保持的影响。
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Cerebral Expression of the Neuregulin-1 Gene NRG1 during Induced Spatial Memory Impairment and Its Reversal in Aging Mice.在诱导的空间记忆损伤和衰老小鼠中的逆转过程中，NRG1 基因在大脑中的表达。
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p-Chloro-diphenyl diselenide reverses memory impairment-related to stress caused by corticosterone and modulates hippocampal [(3)H]glutamate uptake in mice.对氯二苯基二硒醚可逆转与皮质酮引起的应激相关的记忆损伤，并调节小鼠海马体中[³H]谷氨酸的摄取。
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Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice.谷氨酸抗体逆转了衰老的C57Bl/6小鼠中促炎S100A9蛋白原纤维的失忆效应。
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Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice.谷氨酸抗体促进衰老 C57BL/6 小鼠在 Morris 水迷宫中的空间记忆形成。
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Methamphetamine-sensitized mice are accompanied by memory impairment and reduction of N-methyl-d-aspartate receptor ligand binding in the prefrontal cortex and hippocampus.甲基苯丙胺敏化小鼠伴随着前额叶皮层和海马体中 N-甲基-D-天冬氨酸受体配体结合的记忆损伤和减少。
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本文引用的文献

1
Effect of Glutamate Antibody F(ab)2 Fragments on Memory Changes in Aged C57BL/6 Mice.谷氨酸抗体 F(ab')2 片段对老年 C57BL/6 小鼠记忆变化的影响。
Bull Exp Biol Med. 2023 Oct;175(6):762-764. doi: 10.1007/s10517-023-05941-9. Epub 2023 Nov 21.
2
Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.抗谷氨酸抗体对衰老C57BL/6小鼠的行为和神经化学延迟效应
Bull Exp Biol Med. 2021 May;171(1):19-22. doi: 10.1007/s10517-021-05163-x. Epub 2021 May 28.
3
Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice.
谷氨酸抗体逆转了衰老的C57Bl/6小鼠中促炎S100A9蛋白原纤维的失忆效应。
Bull Exp Biol Med. 2017 Feb;162(4):430-432. doi: 10.1007/s10517-017-3632-2. Epub 2017 Feb 27.
4
Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain.白细胞介素-6 基因（IL-6）：在健康成人大脑中对大脑形态的可能作用。
J Neuroinflammation. 2012 Jul 6;9:125. doi: 10.1186/1742-2094-9-125.
5
Antiamnestic effects of antibodies to glutamate in experimental Alzheimer's disease.实验性阿尔茨海默病中谷氨酸抗体的抗遗忘作用
Bull Exp Biol Med. 2010 Dec;150(1):23-5. doi: 10.1007/s10517-010-1058-1.
6
Neuroinflammatory processes in Alzheimer's disease.阿尔茨海默病中的神经炎症过程。
J Neural Transm (Vienna). 2010 Aug;117(8):919-47. doi: 10.1007/s00702-010-0438-z. Epub 2010 Jul 15.
7
Interleukin-6 in the aging brain.衰老大脑中的白细胞介素-6
J Neuroimmunol. 2004 Feb;147(1-2):141-4. doi: 10.1016/j.jneuroim.2003.10.031.