Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
Bull Exp Biol Med. 2020 May;169(1):5-8. doi: 10.1007/s10517-020-04812-x. Epub 2020 May 31.
Intranasal administration of antibodies to glutamate in a dose of 250 μg/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57BL/6 mice. In animals treated with glutamate antibodies, the content of serotonin and dopamine metabolites 3-MT and HVA in the hippocampus decreased, but no changes in the metabolism of neurotransmitter acids were revealed. In the prefrontal cortex, dopamine level decreased and the content of its metabolite DOPAC increased; in parallel, an increase in excitatory and inhibitory amino acids (aspartic acid, glutamate, glycine, taurine, and GABA) was observed.
鼻腔内给予 250μg/kg 的谷氨酸抗体两周，可促进衰老 C57BL/6 小鼠在 Morris 水迷宫中的空间学习和记忆形成。在接受谷氨酸抗体治疗的动物中，海马体中 3-MT 和 HVA 这两种 5-羟色胺和多巴胺代谢物的含量下降，但神经递质酸的代谢没有变化。在前额叶皮层中，多巴胺水平下降，其代谢物 DOPAC 的含量增加；与此同时，观察到兴奋性和抑制性氨基酸（天冬氨酸、谷氨酸、甘氨酸、牛磺酸和 GABA）增加。
