Gevorgyan M M, Voronina N P, Goncharova N V, Kozaruk T V, Russkikh G S, Bogdanova L A, Korolenko T A
Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
Research Institute of Biochemistry, Novosibirsk, Russia.
Bull Exp Biol Med. 2017 Feb;162(4):421-424. doi: 10.1007/s10517-017-3630-4. Epub 2017 Feb 27.
The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide.
半胱氨酸蛋白酶抑制剂胱抑素C作为冠心病（CHD）患者急性心血管事件的替代且有效的预测指标的作用，已得到研究，并与其他心肾异常标志物进行了比较。冠心病患者血清胱抑素C升高，尤其是在有严重心血管并发症风险的病例中。与其他心肾功能障碍指标相比，胱抑素C可被视为心血管并发症的替代预测指标，尽管其敏感性低于高敏C反应蛋白和利钠肽。
