Huang Chiung-Yao, Chang Che-Wei, Tseng Yen-Ju, Lee Jessica, Sung Ping-Jyun, Su Jui-Hsin, Hwang Tsong-Long, Dai Chang-Feng, Wang Hui-Chun, Sheu Jyh-Horng
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Mar Drugs. 2016 Oct 11;14(10):180. doi: 10.3390/md14100180.
Three new steroids, petasitosterones A and B ( and ) and a spirosteroid petasitosterone C (), along with eight known steroids (-), were isolated from a Formosan marine soft coral . The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds - and displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas and exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds - were also examined to evaluate the anti-inflammatory potential, and - were shown to exhibit significant activities.
从一种台湾海洋软珊瑚中分离出三种新的甾体化合物，即佩塔西甾酮A和B（ 和 ）以及一种螺甾类化合物佩塔西甾酮C（ ），同时还分离出了八种已知的甾体化合物（ - ）。通过广泛的光谱分析以及将光谱数据与已报道的数据进行比较，阐明了这些化合物的结构。化合物 是一种具有罕见的A/B螺[4,5]癸烷环系统的海洋甾体。化合物 - 和 对一组有限的癌细胞系的增殖显示出抑制活性，而 和 表现出显著的抗炎活性，可抑制一氧化氮（NO）的产生。还检测了化合物 - 对超氧阴离子生成和弹性蛋白酶释放的抑制活性，以评估其抗炎潜力，结果表明 - 具有显著活性。
