“解码与理解”：自闭症儿童阅读理解背后的大脑反应
"Decoding versus comprehension": Brain responses underlying reading comprehension in children with autism.
作者信息
Bednarz Haley M, Maximo Jose O, Murdaugh Donna L, O'Kelley Sarah, Kana Rajesh K
机构信息
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Brain Lang. 2017 Jun;169:39-47. doi: 10.1016/j.bandl.2017.01.002. Epub 2017 Feb 24.
Despite intact decoding ability, deficits in reading comprehension are relatively common in children with autism spectrum disorders (ASD). However, few neuroimaging studies have tested the neural bases of this specific profile of reading deficit in ASD. This fMRI study examined activation and synchronization of the brain's reading network in children with ASD with specific reading comprehension deficits during a word similarities task. Thirteen typically developing children and 18 children with ASD performed the task in the MRI scanner. No statistically significant group differences in functional activation were observed; however, children with ASD showed decreased functional connectivity between the left inferior frontal gyrus (LIFG) and the left inferior occipital gyrus (LIOG). In addition, reading comprehension ability significantly positively predicted functional connectivity between the LIFG and left thalamus (LTHAL) among all subjects. The results of this study provide evidence for altered recruitment of reading-related neural resources in ASD children and suggest specific weaknesses in top-down modulation of semantic processing.
尽管自闭症谱系障碍（ASD）儿童的解码能力完好，但阅读理解缺陷在他们中相对常见。然而，很少有神经影像学研究测试过ASD中这种特定阅读缺陷特征的神经基础。这项功能磁共振成像（fMRI）研究在一项单词相似性任务中，检查了有特定阅读理解缺陷的ASD儿童大脑阅读网络的激活和同步情况。13名发育正常的儿童和18名ASD儿童在磁共振成像扫描仪中完成了该任务。未观察到功能激活方面有统计学意义的组间差异；然而，ASD儿童在左额下回（LIFG）和左枕下回（LIOG）之间的功能连接有所减少。此外，在所有受试者中，阅读理解能力显著正向预测了LIFG与左丘脑（LTHAL）之间的功能连接。本研究结果为ASD儿童阅读相关神经资源的募集改变提供了证据，并表明在语义处理的自上而下调节方面存在特定弱点。
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