Lan Zhihong, Xu Shoujun, Wu Yunfan, Xia Likun, Hua Kelei, Li Meng, Liu Mengchen, Yin Yi, Li Chunlong, Huang Shumei, Feng Ying, Jiang Guihua, Wang Tianyue
Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.
Department of Radiology, Shenzhen Children's Hospital, Shenzhen, China.
Front Neurosci. 2021 Mar 22;15:644543. doi: 10.3389/fnins.2021.644543. eCollection 2021.
The study was aimed at investigating the alterations of local spontaneous brain activity in preschool boys with autism spectrum disorders (ASD).
Based on regional homogeneity (ReHo), the acquired resting state functional magnetic resonance imaging (fMRI) data sets, which included 86 boys with ASD and 54 typically developing (TD) boys, were used to detect regional brain activity. Pearson correlation analysis was used to study the relationship between abnormal ReHo value and the Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), developmental quotient, and age.
In the ASD group, we found increased ReHo in the right calcarine as well as decreased ReHo in the opercular part of the left inferior frontal gyrus, the left middle temporal gyrus, the left angular gyrus, and the right medial orbital frontal cortex ( < 0.05, false discovery rate correction). We did not find a correlation between the results of brain regions and the CARS, ABC, and age.
Our study found spontaneous activity changes in multiple brain regions, especially the visual and language-related areas of ASD, that may help to further understand the clinical characteristics of boys with ASD.
本研究旨在调查自闭症谱系障碍（ASD）学龄前男孩局部脑自发活动的改变。
基于局部一致性（ReHo），利用采集到的静息态功能磁共振成像（fMRI）数据集（包括86名ASD男孩和54名发育正常（TD）男孩）来检测脑区活动。采用Pearson相关分析研究ReHo异常值与儿童自闭症评定量表（CARS）、自闭症行为量表（ABC）、发育商和年龄之间的关系。
在ASD组中，我们发现右侧距状区的ReHo增加，而左侧额下回岛盖部、左侧颞中回、左侧角回和右侧眶额内侧皮质的ReHo降低（<0.05，错误发现率校正）。我们未发现脑区结果与CARS、ABC及年龄之间存在相关性。
我们的研究发现多个脑区的自发活动发生改变，尤其是ASD患儿的视觉和语言相关区域，这可能有助于进一步了解ASD男孩的临床特征。
