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百里香酚对大鼠电离辐射诱导的唾液腺功能障碍的辐射防护作用。

Radioprotective Effect of Thymol Against Salivary Glands Dysfunction Induced by Ionizing Radiation in Rats.

作者信息

Abedi Seyed Mohammad, Yarmand Fateme, Motallebnejad Mina, Seyedmajidi Maryam, Moslemi Dariush, Bijani Ali, Hosseinimehr Seyed Jalal

机构信息

Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Oral Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iran.; Cellular and Biology Research Center, Babol University of Medical Science, Babol, Iran.

出版信息

Iran J Pharm Res. 2016 Fall;15(4):861-866.

PMID:28243283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5316265/
Abstract

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to ionizing radiation at dose 15 Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Ionizing radiation caused significant salivary glands dysfunction at the 3 and the 70 days with reduction in radioactivity uptake in salivary glands. Ratios of salivary gland to background radioactivities were 2.0 ± 0.05, 1.58 ± 0.62 and 1.99 ± 0.07 at 3 days for control, radiation, and thymol plus radiation groups, respectively. Thymol significantly protected acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats.This finding may have been a promising application of thymol for the protection of salivary glands dysfunction induced by ionizing irradiation in patients exposed to radiation in head and neck cancer therapy.

摘要

本研究的目的是探讨天然产物百里酚对大鼠电离辐射诱导的唾液腺功能障碍的辐射防护作用。在大鼠接受15 Gy剂量的电离辐射前，用50 mg/Kg剂量的百里酚对其进行处理。用放射性核素闪烁扫描法评估唾液腺功能，然后计算唾液腺与背景计数比值。电离辐射在第3天和第70天时导致显著的唾液腺功能障碍，唾液腺放射性摄取减少。对照组、辐射组和百里酚加辐射组在第3天时唾液腺与背景放射性的比值分别为2.0±0.05、1.58±0.62和1.99±0.07。百里酚显著保护了大鼠电离辐射诱导的急性和慢性唾液腺功能障碍。这一发现可能为百里酚在保护头颈癌放疗受照患者电离辐射诱导的唾液腺功能障碍方面提供了一个有前景的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0051/5316265/7cbc0687169c/ijpr-15-861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0051/5316265/7cbc0687169c/ijpr-15-861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0051/5316265/7cbc0687169c/ijpr-15-861-g001.jpg

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