Juliana Norsham, Shahar Suzana, Sahar Mohd Azmani, Ghazali Ahmad Rohi, Manaf Zahara Abdul, Noah Rahim Md
Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia.
Dietetics Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia. Email:
Asia Pac J Clin Nutr. 2017 Mar;26(2):278-286. doi: 10.6133/apjcn.122015.05.
Nutrition and physical activity interventions is beneficial in reversing obesity. However far too little attention has been paid to the effect of these interventions on breast tissues. Thus, the aim of this study was to explore the effect of a home-based dietary and physical activity intervention (the Her Shape Program) on metabolic parameters, blood biomarkers and adiposity at the breast.
A randomized controlled study was conducted on obese women with high breast adiposity (<0.1 Sm-1), aged 40-60 years in Klang Valley, Malaysia. Subjects were assigned to intervention (n=16) and control group (n=15). Intervention group received a home based health education package with close monitoring weekly, personal diet consultation and physical training in group. Assessment was ascertained at three time points; baseline, weeks 8 and 16. Outcome measures were the energy intake, physical activity, body composition, blood tests, blood biomarkers and electrical impedance tomography (EIT) quantitative values. Analyses were done using 2-way repeated measures ANOVA.
All subjects completed the program without any drop-out. The HSI group had 100% compliance towards the intervention program; their energy intake was reduced for approximately 35% and their activity score was increased for approximately 11%. A significant interaction effect was found in body weight, body mass index (BMI), total cholesterol/HDL, vitamin C intake and matrix metallopeptidase 9 (MMP-9) (p<0.05). Interestingly, their EIT extremum values were also significantly increased indicating a reduction of breast adiposity. The intervention program was successful in improving body composition, physical activities, MMP9 and breast adipose tissue composition.
营养和身体活动干预有助于逆转肥胖。然而，这些干预对乳腺组织的影响却很少受到关注。因此，本研究旨在探讨一项居家饮食和身体活动干预（“她的身材计划”）对代谢参数、血液生物标志物及乳腺脂肪含量的影响。
对马来西亚巴生谷地区40 - 60岁、乳腺脂肪含量高（<0.1 Sm-1）的肥胖女性进行了一项随机对照研究。受试者被分为干预组（n = 16）和对照组（n = 15）。干预组接受了一套居家健康教育套餐，每周密切监测，提供个人饮食咨询并进行集体体育训练。在三个时间点进行评估：基线、第8周和第16周。结果指标包括能量摄入、身体活动、身体成分、血液检测、血液生物标志物及电阻抗断层扫描（EIT）定量值。采用双向重复测量方差分析进行分析。
所有受试者均完成了该项目，无一人退出。HSI组对干预项目的依从率为100%；她们的能量摄入减少了约35%，活动得分增加了约11%。在体重、体重指数（BMI）、总胆固醇/高密度脂蛋白、维生素C摄入量和基质金属蛋白酶9（MMP - 9）方面发现了显著的交互作用（p<0.05）。有趣的是，她们的EIT极值也显著增加，表明乳腺脂肪含量减少。该干预项目成功改善了身体成分、身体活动、MMP9及乳腺脂肪组织成分。
