Anderson James W, Fuller Jennifer, Patterson Katy, Blair Robert, Tabor Aaron
Department of Internal Medicine, University of Kentucky, Lexington, KY 40504, USA.
Metabolism. 2007 Feb;56(2):280-8. doi: 10.1016/j.metabol.2006.10.013.
Recent studies suggest that obese individuals lose weight more rapidly and lose more total weight with soy protein than with animal protein as a major diet component. The purpose of the present study was to evaluate the weight-loss efficacy and changes in body composition, waist circumference, blood pressure, and levels of plasma glucose, insulin, serum lipids, C-reactive protein, and homocysteine from consumption of either 3 soy shakes or 3 casein shakes daily as part of a 16-week, energy-restricted diet for obese women. Forty-three women with body mass index values of 30 to 40 kg/m(2) were randomized to intensive dietary interventions using either casein (n = 21) or soy (n = 22) shakes. Subjects were instructed to consume 3 shakes, 1 prepackaged entrée, and 5 servings of fruits or vegetables daily to achieve an energy intake of 4.5 to 5.0 MJ/d. Subjects attended classes weekly or biweekly. Weight, body fat, lipid, and glucose measurements were obtained at baseline and at 8 and 16 weeks. For both groups combined, subjects lost 8.1% of initial body weight (7.7 kg) at 8 weeks and 13.4% (12.7 kg) at 16 weeks. Weight loss from baseline did not differ significantly by group and, for completing subjects, was 14.0% +/- 1.2% (mean +/- SE) for casein and 12.8% +/- 1.4% for soy. With the intention-to-treat analysis, weight losses at 16 weeks were 12.5% +/- 1.4% for casein and 11.3% +/- 1.2% for soy. Body fat losses were 23.7% +/- 2.0% for casein and 21.8% +/- 2.4% for soy and did not differ significantly. Both study groups lost significant amounts of weight with a highly structured behavioral program incorporating 4 meal replacements and vegetables and fruits. Differences in weight loss and body composition changes between casein and soy treatments were not significant.
近期研究表明，在以大豆蛋白而非动物蛋白作为主要饮食成分时，肥胖个体体重减轻得更快，且总体减重更多。本研究的目的是评估肥胖女性在16周能量限制饮食期间，每日饮用3份大豆奶昔或3份酪蛋白奶昔后，其减肥效果以及身体成分、腰围、血压、血浆葡萄糖水平、胰岛素、血脂、C反应蛋白和同型半胱氨酸的变化情况。43名体重指数在30至40kg/m²的女性被随机分为两组，分别接受使用酪蛋白奶昔（n = 21）或大豆奶昔（n = 22）的强化饮食干预。受试者被要求每日饮用3份奶昔、1份预包装主餐，并摄入5份水果或蔬菜，以使能量摄入达到4.5至5.0MJ/天。受试者每周或每两周参加课程。在基线、8周和16周时测量体重、体脂、血脂和血糖。两组受试者综合来看，在8周时体重减轻了初始体重的8.1%（7.7kg），在16周时减轻了13.4%（12.7kg）。两组间基线体重减轻差异不显著，完成试验的受试者中，酪蛋白组体重减轻了14.0%±1.2%（均值±标准误），大豆组为12.8%±1.4%。在意向性分析中，16周时酪蛋白组体重减轻了12.5%±1.4%，大豆组为11.3%±1.2%。酪蛋白组体脂减少了23.7%±2.0%，大豆组为21.8%±2.4%，差异不显著。两个研究组通过包含4份代餐以及蔬菜和水果的高度结构化行为计划都实现了显著的体重减轻。酪蛋白组和大豆组在体重减轻和身体成分变化方面的差异不显著。
