一种基于柱[5]芳烃的用于光动力治疗的线粒体靶向超分子光敏剂。
A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy.
作者信息
Rui Leilei, Xue Yudong, Wang Yong, Gao Yun, Zhang Weian
机构信息
Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China.
出版信息
Chem Commun (Camb). 2017 Mar 9;53(21):3126-3129. doi: 10.1039/c7cc00950j.
A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (O) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.
基于主客体包合物构建了一种线粒体靶向超分子光敏剂体系TPP-QAS/WP5/DTAB。该超分子体系能够在酸性环境中高效释放并激活TPP-QASs，已证明这些物质优先在线粒体中积累。在光照下，单线态氧（O）可在线粒体中原位生成，进一步提高光动力治疗效果。
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