Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
ACS Appl Mater Interfaces. 2020 Jul 22;12(29):32352-32359. doi: 10.1021/acsami.0c07333. Epub 2020 Jul 9.
Supramolecular polymers with facile and versatile architectures via noncovalent connection present great potential in biological fields. Herein, a linear alternating supramolecular polymer is constructed via host-guest inclusion interaction between cyclodextrin dimer (CD) and bifunctional adamantane-conjugated porphyrin (TPP-Ad). The supramolecular alternating structure of CD/TPP could not only suppress the aggregation of PSs to improve the photophysical properties because of the steric hindrance but also enhance the water solubility of PSs induced from cyclodextrin moieties. The nanoplatform obtained by this linear alternating supramolecular polymer (TPP-Ad/CD) presents significantly enhanced photodynamic therapy (PDT) efficacy, providing a promising path for PDT.
通过非共价键连接构建具有简便多样结构的超分子聚合物，在生物领域具有巨大的应用潜力。在此，通过环糊精二聚体 (CD) 和双官能金刚烷偶联卟啉 (TPP-Ad) 之间的主客体包合相互作用，构建了一种线性交替超分子聚合物。CD/TPP 的超分子交替结构不仅可以通过空间位阻抑制 PS 的聚集，从而改善光物理性质，而且还可以通过环糊精部分诱导 PS 提高水溶性。通过这种线性交替超分子聚合物 (TPP-Ad/CD) 获得的纳米平台表现出显著增强的光动力治疗 (PDT) 效果，为 PDT 提供了一条很有前途的途径。
