Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, China.
Center of College of Science & Technology, Hebei Agricultural University, Huanghua 061100, China.
Molecules. 2021 Jun 25;26(13):3878. doi: 10.3390/molecules26133878.
Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to overcome these problems, we prepared a supramolecular photosensitive system of O-Cu/ZIF-8@ZIF-8@WP6-MB (OCZWM), which was loaded with oxygen to increase the oxygen concentration in the tumor microenvironment, and the Cu in the system reacted with glutathione (GSH) to reduce the GSH concentration to generate Cu. It is worth noting that the generated Cu can produce the Fenton reaction, thus realizing the combination therapy of PDT and chemodynamic therapy (CDT) to achieve the purpose of significantly improving the anti-cancer efficiency.
光动力疗法（PDT）作为一种安全、非侵入性的癌症治疗方法，其在肿瘤微环境中低氧和高谷胱甘肽会降低治疗效率。为了克服这些问题，我们制备了一种超分子光敏体系 O-Cu/ZIF-8@ZIF-8@WP6-MB（OCZWM），它负载了氧气以增加肿瘤微环境中的氧浓度，并且体系中的铜与谷胱甘肽（GSH）反应以降低 GSH 浓度来生成铜。值得注意的是，生成的铜可以产生芬顿反应，从而实现光动力治疗和化学动力学治疗（CDT）的联合治疗，达到显著提高抗癌效率的目的。
