Bendardaf Riyad, El-Serafi Ahmed, Syrjänen Kari, Collan Yrjö, Pyrhönen Seppo
a Department of Medical Oncology , University Sharjah Hospital , Sharjah , United Arab Emirates.
b College of Medicine , University of Sharjah , Sharjah , United Arab Emirates.
Libyan J Med. 2017 Dec;12(1):1290741. doi: 10.1080/19932820.2017.1290741.
Colorectal cancer is third leading cause of cancer mortality. About 60% of patients had already developed metastasis at the time of diagnosis. Vascular endothelial growth factor (VEGF) is crucial for the development of neovascularization and hence metastasis. This study aimed at investigating the relation between the expression of VEGF in biopsies from surgically dissected colon cancer and the survival of those patients. Biopsies were collected from 86 patients with advanced colon cancer and sections were stained by immunohistochemistry for VEGF. Patients received chemotherapy after the operation and were followed up for disease progression and survival. The clinical data were statistically analyzed with respect to the immunohistochemistry results. The survival of the patients was significantly longer in the patients for whom biopsies showed negative or weak expression of VEGF in comparison to those with moderate to high expression (p-value = 0.04). The expression of VEGF was more frequent in the patients who died as a consequence of the disease in comparison to the 10-year survivors. In conclusion, VEGF could be related to the survival of the patients with colorectal carcinoma and should be considered as a predictor of the prognosis.
结直肠癌是癌症死亡的第三大主要原因。约60%的患者在诊断时已发生转移。血管内皮生长因子（VEGF）对于新血管形成及转移的发展至关重要。本研究旨在调查手术切除的结肠癌活检组织中VEGF的表达与这些患者生存情况之间的关系。收集了86例晚期结肠癌患者的活检组织，并通过免疫组织化学对VEGF进行染色。患者术后接受化疗，并对疾病进展和生存情况进行随访。根据免疫组织化学结果对临床数据进行统计学分析。与VEGF表达为中度至高表达的患者相比，活检显示VEGF表达为阴性或弱阳性的患者生存时间显著更长（p值 = 0.04）。与10年生存者相比，因该疾病死亡的患者中VEGF表达更为常见。总之，VEGF可能与结直肠癌患者的生存情况相关，应被视为预后的一个预测指标。
