Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia.
School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
PLoS One. 2021 Mar 10;16(3):e0247492. doi: 10.1371/journal.pone.0247492. eCollection 2021.
Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung cancer (A549), human ovarian cancer (SKOV-3), pro-monocytic human leukemia (U937) and to mouse melanoma (B16) cell lines; whereas no effects were noted on human breast (ZR-75-1) and human colon (HT29) cancer cell lines, as well as to human normal colon epithelial cell line (T4056). Anti-proliferative effects were shown to be mediated via alteration in cytokines, VEGF-1 and NF-κB expression.
植物多酚具有多种健康益处，主要被认为与其高含量的抗氧化剂有关。这些抗氧化剂通常被低估了，其生物特性的知识在过去十年中呈指数级增长。富含多酚的甘蔗提取物（PRSE）是一种从甘蔗中提取的天然提取物，因其富含抗氧化剂和多酚而被推向市场，但之前并未报道其抗癌活性。我们表明，PRSE 对多种癌细胞具有抗癌特性，包括人（LIM2045）和鼠（MC38、CT26）结肠癌细胞系；人肺癌（A549）、人卵巢癌（SKOV-3）、单核细胞前白血病（U937）和鼠黑色素瘤（B16）细胞系；而对人乳腺癌（ZR-75-1）和人结肠癌（HT29）细胞系以及人正常结肠上皮细胞系（T4056）没有影响。抗增殖作用是通过改变细胞因子、VEGF-1 和 NF-κB 的表达来介导的。
