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亚太地区因呼吸困难就诊于急诊科的心力衰竭患者:一项观察性研究。

Heart failure in patients presenting with dyspnoea to the emergency department in the Asia Pacific region: an observational study.

机构信息

Department of Emergency Medicine, Gold Coast University Hospital, Gold Coast, Queensland, Australia.

School of Medicine, Bond University, Gold Coast, Queensland, Australia.

出版信息

BMJ Open. 2017 Feb 28;7(2):e013812. doi: 10.1136/bmjopen-2016-013812.

DOI:10.1136/bmjopen-2016-013812
PMID:28246137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5337741/
Abstract

OBJECTIVES

To describe demographic features, assessment, management and outcomes of patients who were diagnosed with heart failure after presenting to an emergency department (ED) with a principal symptom of dyspnoea.

DESIGN

Planned substudy of the prospective, descriptive cohort study: Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM).

SETTING

46 EDs in Australia, New Zealand, Singapore, Hong Kong and Malaysia collected data over 3 72-hour periods in May, August and October 2014.

PARTICIPANTS

Patients with an ED diagnosis of heart failure.

OUTCOME MEASURES

Outcomes included patient epidemiology, investigations ordered, treatment modalities used and patient outcomes (hospital length of stay (LOS) and mortality).

RESULTS

455 (14.9%) of the 3044 patients had an ED diagnosis of heart failure. Median age was 79 years, half were male and 62% arrived via ambulance. 392 (86%) patients were admitted to hospital. ED diagnosis was concordant with hospital discharge diagnosis in 81% of cases. Median hospital LOS was 6 days (IQR 4-9) and in-hospital mortality was 5.1%. Natriuretic peptide levels were ordered in 19%, with lung ultrasound (<1%) and echocardiography (2%) uncommonly performed. Treatment modalities included non-invasive ventilation (12%), diuretics (73%), nitrates (25%), antibiotics (16%), inhaled β-agonists (13%) and corticosteroids (6%).

CONCLUSIONS

In the Asia Pacific region, heart failure is a common diagnosis among patients presenting to the ED with a principal symptom of dyspnoea. Admission rates were high and ED diagnostic accuracy was good. Despite the seemingly suboptimal adherence to investigation and treatment guidelines, patient outcomes were favourable compared with other registries.

摘要

目的

描述以呼吸困难为主要症状就诊于急诊科的患者被诊断为心力衰竭后的人口统计学特征、评估、管理和结局。

设计

前瞻性描述性队列研究的计划子研究:亚洲、澳大利亚和新西兰急诊科呼吸困难研究(AANZDEM)。

设置

2014 年 5 月、8 月和 10 月,澳大利亚、新西兰、新加坡、中国香港和马来西亚的 46 家急诊科在 3 个 72 小时期间收集数据。

参与者

急诊科诊断为心力衰竭的患者。

结局测量

结局包括患者流行病学、所开检查、所使用的治疗方式和患者结局(住院时间长短和死亡率)。

结果

在 3044 例患者中,有 455 例(14.9%)被急诊科诊断为心力衰竭。中位年龄为 79 岁,一半为男性,62%通过救护车到达。392 例(86%)患者被收入住院。急诊科诊断与出院诊断相符的比例为 81%。中位住院时间为 6 天(四分位距 4-9),院内死亡率为 5.1%。19%的患者进行了利钠肽水平检测,很少进行肺部超声(<1%)和超声心动图(2%)检查。治疗方式包括无创通气(12%)、利尿剂(73%)、硝酸盐(25%)、抗生素(16%)、吸入β-激动剂(13%)和皮质激素(6%)。

结论

在亚太地区,以呼吸困难为主要症状就诊于急诊科的患者心力衰竭的常见诊断。住院率较高,急诊科诊断准确性较好。尽管对检查和治疗指南的依从性似乎不理想,但与其他登记处相比,患者结局较好。

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本文引用的文献

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An Observational Study of Dyspnea in Emergency Departments: The Asia, Australia, and New Zealand Dyspnea in Emergency Departments Study (AANZDEM).急诊科呼吸困难的观察性研究:亚洲、澳大利亚和新西兰急诊科呼吸困难研究(AANZDEM)。
Acad Emerg Med. 2017 Mar;24(3):328-336. doi: 10.1111/acem.13118.
2
Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine.急性心力衰竭院前及早期医院管理建议:欧洲心脏病学会心力衰竭协会、欧洲急诊医学会和急诊医学学术学会联合共识文件。
Eur J Heart Fail. 2015 Jun;17(6):544-58. doi: 10.1002/ejhf.289. Epub 2015 May 21.
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Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM) study: Rationale, design and analysis.亚洲、澳大利亚和新西兰急诊科呼吸困难(AANZDEM)研究:原理、设计与分析。
Emerg Med Australas. 2015 Jun;27(3):187-91. doi: 10.1111/1742-6723.12397. Epub 2015 May 4.
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Lung Ultrasound-Implemented Diagnosis of Acute Decompensated Heart Failure in the ED: A SIMEU Multicenter Study.急诊科应用肺部超声诊断急性失代偿性心力衰竭:一项SIMEU多中心研究
Chest. 2015 Jul;148(1):202-210. doi: 10.1378/chest.14-2608.
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Heart failure diagnosis in acute conditions has high agreement with inpatient diagnosis.急性情况下的心衰诊断与住院诊断高度一致。
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The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.心力衰竭住院患者的全球健康和经济负担:从心力衰竭住院登记中吸取的经验教训。
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2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.2013年美国心脏病学会基金会/美国心脏协会心力衰竭管理指南:美国心脏病学会基金会/美国心脏协会实践指南工作组报告
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Natriuretic peptide-guided therapy in chronic heart failure: a meta-analysis of 2,686 patients in 12 randomized trials.利钠肽指导的慢性心力衰竭治疗:12 项随机试验中 2686 例患者的荟萃分析。
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Is hospital admission for heart failure really necessary?: the role of the emergency department and observation unit in preventing hospitalization and rehospitalization.心力衰竭患者真的需要住院治疗吗?:急诊科和观察单元在预防住院和再住院中的作用。
J Am Coll Cardiol. 2013 Jan 15;61(2):121-6. doi: 10.1016/j.jacc.2012.08.1022.
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ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC.《2012年欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南》:欧洲心脏病学会2012年急性和慢性心力衰竭诊断与治疗特别工作组。与欧洲心脏病学会心力衰竭协会(HFA)合作制定。
Eur J Heart Fail. 2012 Aug;14(8):803-69. doi: 10.1093/eurjhf/hfs105.