Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018.
Key Laboratory for Regenerative Medicine of Ministry of Education and Department of Developmental & Regenerative Biology, Jinan University, Guangzhou 510632, P.R. China.
Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12):a027870. doi: 10.1101/cshperspect.a027870.
Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton orchestrated by signaling molecules such as the Rho family of small GTPases. Elucidating the molecular mechanisms of polarized exocytosis is essential to our understanding of a wide range of pathophysiological processes from neuronal development to tumor invasion.
极化分泌通常被认为是一个多步骤的囊泡运输过程，在此过程中，膜结合载体从高尔基体或内体区室运输到质膜的特定部位。细胞中的极化分泌是通过膜运输机制和细胞骨架的协调作用来实现的，这一过程由信号分子如 Rho 家族的小分子 GTPases 来协调。阐明极化分泌的分子机制对于我们理解从神经元发育到肿瘤侵袭等广泛的病理生理过程至关重要。
