Myers Kenneth R, Casanova James E
Department of Cell Biology, University of Virginia Health System, Charlottesville, VA 22908-0732, USA.
Trends Cell Biol. 2008 Apr;18(4):184-92. doi: 10.1016/j.tcb.2008.02.002. Epub 2008 Mar 6.
Small GTPases of the Arf family are best known for their role in vesicular transport, wherein they nucleate the assembly of coat proteins at sites of carrier vesicle formation. However, accumulating evidence indicates that the Arfs are also important regulators of actin cytoskeleton dynamics and are involved in a variety of actin-based processes, including cell adhesion, migration and neurite outgrowth. The mechanisms of this regulation are remarkably diverse, ranging from the integration of vesicular transport with cytoskeleton assembly to the direct regulation of Rho-family GTPase function. Here, we review recent progress in our understanding of how Arfs and their interacting proteins function to integrate membrane and cytoskeletal dynamics.
Arf家族的小GTP酶因其在囊泡运输中的作用而最为人所知，在囊泡运输过程中，它们在载体囊泡形成位点促使衣被蛋白组装。然而，越来越多的证据表明，Arf蛋白也是肌动蛋白细胞骨架动力学的重要调节因子，并参与多种基于肌动蛋白的过程，包括细胞黏附、迁移和神经突生长。这种调节机制非常多样，从囊泡运输与细胞骨架组装的整合到对Rho家族GTP酶功能的直接调节。在这里，我们综述了我们对Arf蛋白及其相互作用蛋白如何整合膜和细胞骨架动力学的最新认识进展。
