Wang Wen-Hung, Hsuan Kuo-Yu, Chu Ling-Ya, Lee Chia-Ying, Tyan Yu-Chang, Chen Zong-Shiow, Tsai Wan-Chi
Department of Otolaryngology, Cathay General Hospital, Taipei City 106, Taiwan; Department of Otolaryngology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan; School of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan.
Department of Hemato-Oncology, Chi-Mei Medical Center, Tainan City 710, Taiwan.
Evid Based Complement Alternat Med. 2017;2017:5364010. doi: 10.1155/2017/5364010. Epub 2017 Jan 29.
Researchers have reported significant effects from Danshen () in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas. Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2. We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells. Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100 mg/kg, respectively, for 34 days. Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.
研究人员报告称，丹参在抑制乳腺癌、肝细胞癌、早幼粒细胞白血病和透明细胞卵巢癌的肿瘤细胞增殖及促进细胞凋亡方面具有显著作用。在此，我们报告我们的数据，表明丹参提取物，尤其是乙醇提取物，能显著抑制人口腔鳞状细胞癌（OSCC）细胞系HSC-3和OC-2的增殖。我们还观察到，丹参乙醇提取物通过阻碍凋亡抑制蛋白（IAP）家族成员来激活半胱天冬酶-3凋亡执行因子，而不是通过调节OSCC细胞中Bcl-2触发的线粒体途径。我们的数据还表明，该提取物在体内发挥了有前景的作用，用50和100mg/kg的丹参乙醇提取物分别处理34天后，HSC-3肿瘤异种移植物的生长分别被抑制了40%和69%。综合来看，我们的结果表明丹参乙醇提取物作为一种天然抗氧化剂和草药类人类口腔癌化学预防药物具有明显的抗癌活性和巨大潜力。
