轮状病毒特异性细胞毒性T淋巴细胞可被动保护乳鼠免受肠胃炎侵害。
Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice.
作者信息
Offit P A, Dudzik K I
机构信息
Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania.
出版信息
J Virol. 1990 Dec;64(12):6325-8. doi: 10.1128/JVI.64.12.6325-6328.1990.
Abstract
Suckling mice are protected against murine rotavirus-induced gastroenteritis after adoptive transfer of splenic lymphocytes from immunized animals. Adoptive transfer of Thy1(+)-depleted or CD8(+)-depleted lymphocytes abrogated protection against challenge. (We previously found that depletion of Thy1+ or CD8+ lymphocytes from rotavirus-immunized mice decreased rotavirus-specific cytotoxic activity in vitro.) Protection against disease occurred in the absence of rotavirus-specific neutralizing antibodies in the sera of suckling mice. Rotavirus-specific cytotoxic T lymphocytes may be important in either amelioration of acute infection or protection against reinfection.
摘要
在将免疫动物的脾淋巴细胞进行过继转移后，乳鼠可免受鼠轮状病毒诱导的胃肠炎。过继转移去除Thy1(+)或CD8(+)的淋巴细胞可消除对攻击的保护作用。（我们之前发现，从轮状病毒免疫的小鼠中去除Thy1+或CD8+淋巴细胞会降低体外轮状病毒特异性细胞毒性活性。）在乳鼠血清中不存在轮状病毒特异性中和抗体的情况下也出现了对疾病的保护作用。轮状病毒特异性细胞毒性T淋巴细胞可能在急性感染的改善或预防再感染方面起重要作用。
相似文献
1
Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice.轮状病毒特异性细胞毒性T淋巴细胞可被动保护乳鼠免受肠胃炎侵害。
J Virol. 1990 Dec;64(12):6325-8. doi: 10.1128/JVI.64.12.6325-6328.1990.
2
Recovery from chronic rotavirus infection in mice with severe combined immunodeficiency: virus clearance mediated by adoptive transfer of immune CD8+ T lymphocytes.重度联合免疫缺陷小鼠慢性轮状病毒感染的恢复：免疫CD8 + T淋巴细胞过继转移介导的病毒清除
J Virol. 1990 Sep;64(9):4375-82. doi: 10.1128/JVI.64.9.4375-4382.1990.
3
Noninfectious rotavirus (strain RRV) induces an immune response in mice which protects against rotavirus challenge.非感染性轮状病毒（RRV毒株）可在小鼠体内引发免疫反应，使其免受轮状病毒攻击。
J Clin Microbiol. 1989 May;27(5):885-8. doi: 10.1128/jcm.27.5.885-888.1989.
4
Protection against rotavirus-induced gastroenteritis in a murine model by passively acquired gastrointestinal but not circulating antibodies.在小鼠模型中，通过被动获得的胃肠道抗体而非循环抗体预防轮状病毒引起的肠胃炎。
J Virol. 1985 Apr;54(1):58-64. doi: 10.1128/JVI.54.1.58-64.1985.
5
Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice.用杆状病毒表达的重组轮状病毒蛋白VP1、VP4、VP6和VP7进行免疫接种可诱导CD8 + T淋巴细胞，这些细胞可介导SCID小鼠慢性轮状病毒感染的清除。
J Virol. 1991 Nov;65(11):5928-32. doi: 10.1128/JVI.65.11.5928-5932.1991.
6
Protection of adult but not newborn mice against lethal intracerebral challenge with Japanese encephalitis virus by adoptively transferred virus-specific cytotoxic T lymphocytes: requirement for L3T4+ T cells.通过过继转移病毒特异性细胞毒性T淋巴细胞对成年而非新生小鼠进行保护，使其免受日本脑炎病毒致死性脑内攻击：对L3T4 + T细胞的需求。
J Gen Virol. 1996 Apr;77 ( Pt 4):705-14. doi: 10.1099/0022-1317-77-4-705.
7
Maternal antibody-mediated protection against gastroenteritis due to rotavirus in newborn mice is dependent on both serotype and titer of antibody.母源抗体介导的对新生小鼠轮状病毒肠胃炎的保护作用取决于抗体的血清型和滴度。
J Infect Dis. 1985 Dec;152(6):1152-8. doi: 10.1093/infdis/152.6.1152.
8
Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon.在缺乏穿孔素、Fas和γ干扰素的情况下，CD8 + T细胞对小鼠轮状病毒具有免疫作用的证据。
J Virol. 1997 Jan;71(1):479-86. doi: 10.1128/JVI.71.1.479-486.1997.
9
Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.轮状病毒感染后，轮状病毒特异性细胞毒性T淋巴细胞出现在肠道黏膜表面。
J Virol. 1989 Aug;63(8):3507-12. doi: 10.1128/JVI.63.8.3507-3512.1989.
10
Protection against rotavirus infections by DNA vaccination.
J Infect Dis. 1996 Sep;174 Suppl 1:S93-7. doi: 10.1093/infdis/174.supplement_1.s93.
引用本文的文献
1
B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses.用于研究人轮状病毒疫苗诱导的保护性免疫反应的B细胞缺陷和CD8 T细胞耗竭的无菌猪
Viral Immunol. 2016 Mar;29(2):112-27. doi: 10.1089/vim.2015.0105. Epub 2016 Jan 29.
2
Why does the world need another rotavirus vaccine?为什么世界需要另一种轮状病毒疫苗？
Ther Clin Risk Manag. 2008 Feb;4(1):49-63. doi: 10.2147/tcrm.s821.
3
Rectal immunization with rotavirus virus-like particles induces systemic and mucosal humoral immune responses and protects mice against rotavirus infection.用轮状病毒样颗粒进行直肠免疫可诱导全身和黏膜体液免疫反应，并保护小鼠免受轮状病毒感染。
J Virol. 2006 Feb;80(4):1752-61. doi: 10.1128/JVI.80.4.1752-1761.2006.
4
Memory T-cell response to rotavirus detected with a gamma interferon enzyme-linked immunospot assay.采用γ干扰素酶联免疫斑点试验检测到的针对轮状病毒的记忆性T细胞反应。
J Virol. 2005 May;79(9):5684-94. doi: 10.1128/JVI.79.9.5684-5694.2005.
5
Mucosal immunity: overcoming the barrier for induction of proximal responses.黏膜免疫：克服诱导近端反应的障碍。
Immunol Res. 2004;30(1):35-71. doi: 10.1385/IR:30:1:035.
6
Synthesis of an HIV-1 Tat transduction domain-rotavirus enterotoxin fusion protein in transgenic potato.在转基因马铃薯中合成HIV-1反式激活因子转导结构域-轮状病毒肠毒素融合蛋白
Plant Cell Rep. 2004 Jan;22(6):382-7. doi: 10.1007/s00299-003-0697-3. Epub 2003 Oct 10.
7
Expression of rotavirus capsid protein VP6 in transgenic potato and its oral immunogenicity in mice.轮状病毒衣壳蛋白VP6在转基因马铃薯中的表达及其对小鼠的口服免疫原性。
Transgenic Res. 2003 Apr;12(2):163-9. doi: 10.1023/a:1022912130286.
8
Protective immunity to rotavirus shedding in the absence of interleukin-6: Th1 cells and immunoglobulin A develop normally.在缺乏白细胞介素-6的情况下对轮状病毒脱落的保护性免疫：Th1细胞和免疫球蛋白A正常发育。
J Virol. 2000 Jun;74(11):5250-6. doi: 10.1128/jvi.74.11.5250-5256.2000.
9
Vaccines for mucosal immunity to combat emerging infectious diseases.用于对抗新发传染病的黏膜免疫疫苗。
Emerg Infect Dis. 2000 Mar-Apr;6(2):123-32. doi: 10.3201/eid0602.000204.
10
Adoptive transfer of infectious bronchitis virus primed alphabeta T cells bearing CD8 antigen protects chicks from acute infection.携带CD8抗原的传染性支气管炎病毒致敏αβT细胞的过继转移可保护雏鸡免受急性感染。
Virology. 2000 Mar 30;269(1):183-9. doi: 10.1006/viro.2000.0211.
本文引用的文献
1
2
Cytotoxic T-cell immunity to influenza.针对流感的细胞毒性T细胞免疫
N Engl J Med. 1983 Jul 7;309(1):13-7. doi: 10.1056/NEJM198307073090103.
3
A murine model for oral infection with a primate rotavirus (simian SA11).一种用于灵长类轮状病毒（猿猴SA11）口腔感染的小鼠模型。
J Virol. 1984 Jul;51(1):233-6. doi: 10.1128/JVI.51.1.233-236.1984.
4
Importance of cytotoxic lymphocytes during cytomegalovirus infection in renal transplant recipients.细胞毒性淋巴细胞在肾移植受者巨细胞病毒感染中的重要性。
Am J Med. 1984 Mar;76(3):385-92. doi: 10.1016/0002-9343(84)90655-7.
5
6
Response of mice to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization.通过放射免疫测定、放射免疫沉淀和蚀斑减少中和试验评估小鼠对牛源或灵长类源轮状病毒的反应。
Infect Immun. 1983 Oct;42(1):293-300. doi: 10.1128/iai.42.1.293-300.1983.
7
Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocytes.从致死性1型单纯疱疹病毒感染中恢复是由细胞毒性T淋巴细胞介导的。
Infect Immun. 1983 Jul;41(1):197-204. doi: 10.1128/iai.41.1.197-204.1983.
8
Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients.巨细胞病毒感染中的细胞毒性T细胞：骨髓移植受者中HLA限制性T淋巴细胞和非T淋巴细胞的细胞毒性反应与巨细胞病毒感染的恢复相关。
N Engl J Med. 1982 Jul 1;307(1):7-13. doi: 10.1056/NEJM198207013070102.
9
A two-year study of bacterial, viral, and parasitic agents associated with diarrhea in rural Bangladesh.一项针对孟加拉国农村地区腹泻相关细菌、病毒和寄生虫病原体的为期两年的研究。
J Infect Dis. 1980 Nov;142(5):660-4. doi: 10.1093/infdis/142.5.660.
10
Analysis of the effector functions of different populations of mucosal lymphocytes.黏膜淋巴细胞不同群体的效应功能分析。
Ann N Y Acad Sci. 1983 Jun 30;409:307-20. doi: 10.1111/j.1749-6632.1983.tb26879.x.
Zotero 插件