Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; Institute of Human Performance, The University of Hong Kong, Hong Kong, China; University of Queensland Centre for Clinical Research, University of Queensland, Brisbane, QLD, Australia.
Eur Urol. 2017 Aug;72(2):293-299. doi: 10.1016/j.eururo.2017.02.019. Epub 2017 Feb 27.
Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown.
To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT.
DESIGN, SETTING, AND PARTICIPANTS: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading+resistance training; ILRT; n=58), the cardiovascular and muscular systems (aerobic+resistance training; ART; n=54), or to usual care/delayed exercise (DEL; n=51) for 12 mo across university-affiliated exercise clinics in Australia.
Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise.
Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo.
Fatigue was reduced (p=0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p=0.005) and DEL (p=0.022) at 12 mo. Similarly, vitality increased for all groups (p≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p<0.001). A limitation was inclusion of mostly well-functioning individuals.
Different exercise modes have comparable effects on reducing fatigue and enhancing vitality during ADT. Patients with the highest levels of fatigue and lowest vitality had the greatest benefits.
We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.
体育锻炼可以减轻雄激素剥夺疗法（ADT）期间的疲劳；然而，不同运动方案的效果尚不清楚。
确定不同运动方式对接受 ADT 的前列腺癌患者疲劳的长期影响。
设计、设置和参与者：2009 年至 2012 年，163 名年龄在 43-90 岁之间正在接受 ADT 的前列腺癌患者被随机分配至针对骨骼肌肉系统的运动（冲击负荷+抗阻训练；ILRT；n=58）、心血管和肌肉系统的运动（有氧运动+抗阻训练；ART；n=54）或接受常规护理/延迟运动（DEL；n=51），在澳大利亚的大学附属运动诊所接受为期 12 个月的治疗。
接受 12 个月的监督 ILRT、接受 6 个月的监督 ART 随后是 6 个月的家庭计划、接受 6 个月的运动信息印刷手册随后是 6 个月的固定自行车运动。
使用欧洲癌症研究和治疗组织生活质量问卷核心 36 版评估疲劳，使用健康调查简表 36 评估活力。使用方差分析比较 6 个月和 12 个月时的各组结果。
ILRT 在 6 个月和 12 个月时（约 5 分）、ART（p=0.005）和 DEL（p=0.022）在 12 个月时疲劳减轻，所有组的活力在 12 个月时均增加（p≤0.001）（约 4 分）。运动效果最好的是那些疲劳程度最高和活力最低的患者（p<0.001）。一个局限性是纳入的大多数都是功能良好的个体。
不同的运动模式在减轻 ADT 期间的疲劳和提高活力方面具有相当的效果。疲劳程度最高和活力最低的患者获益最大。
我们比较了不同运动模式对接受雄激素剥夺疗法男性患者疲劳的影响。所有运动方案都减轻了疲劳，增强了活力。我们的结论是，进行某种形式的运动将有助于减轻疲劳，尤其是那些最疲劳的患者。
