• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雌激素受体基因 ESR1、ESR2 和 AR 中的微卫星多态性对大脑结构性别差异的影响。

The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.

机构信息

Institute of Mental Health, National Healthcare Group, Singapore; Clinical Imaging Research Centre, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A(∗)STAR), Singapore.

DeepMind Technologies Limited, United Kingdom, UK.

出版信息

Neuroimage. 2020 Nov 1;221:117087. doi: 10.1016/j.neuroimage.2020.117087. Epub 2020 Jun 25.

DOI:10.1016/j.neuroimage.2020.117087
PMID:32593802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8960998/
Abstract

The androgen receptor (AR), oestrogen receptor alpha (ESR1) and oestrogen receptor beta (ESR2) play essential roles in mediating the effect of sex hormones on sex differences in the brain. Using Voxel-based morphometry (VBM) and gene sizing in two independent samples (discovery n ​= ​173, replication ​= ​61), we determine the common and unique influences on brain sex differences in grey (GM) and white matter (WM) volume between repeat lengths (n) of microsatellite polymorphisms AR(CAG)n, ESR1(TA)n and ESR2(CA)n. In the hypothalamus, temporal lobes, anterior cingulate cortex, posterior insula and prefrontal cortex, we find increased GM volume with increasing AR(CAG)n across sexes, decreasing ESR1(TA)n across sexes and decreasing ESR2(CA)n in females. Uniquely, AR(CAG)n was positively associated with dorsolateral prefrontal and orbitofrontal GM volume and the anterior corona radiata, left superior fronto-occipital fasciculus, thalamus and internal capsule WM volume. ESR1(TA)n was negatively associated with the left superior corona radiata, left cingulum and left inferior longitudinal fasciculus WM volume uniquely. ESR2(CA)n was negatively associated with right fusiform and posterior cingulate cortex uniquely. We thus describe the neuroanatomical correlates of three microsatellite polymorphisms of steroid hormone receptors and their relationship to sex differences.

摘要

雄激素受体 (AR)、雌激素受体 alpha (ESR1) 和雌激素受体 beta (ESR2) 在介导性激素对大脑性别差异的影响方面发挥着重要作用。使用体素基形态计量学 (VBM) 和基因大小分析在两个独立样本（发现样本 n=173，复制样本 n=61）中，我们确定了 AR(CAG)n、ESR1(TA)n 和 ESR2(CA)n 微卫星多态性重复长度 (n) 对灰质 (GM) 和白质 (WM) 体积脑性别差异的共同和独特影响。在下丘脑、颞叶、前扣带皮层、后岛叶和前额叶皮层中，我们发现 AR(CAG)n 增加与 GM 体积增加有关，跨性别 ESR1(TA)n 减少，女性 ESR2(CA)n 减少。独特的是，AR(CAG)n 与背外侧前额叶和眶额 GM 体积以及前放射冠、左侧额顶额束、丘脑和内囊 WM 体积呈正相关。ESR1(TA)n 与左侧放射冠、左侧扣带束和左侧下纵束 WM 体积的负相关是独特的。ESR2(CA)n 与右侧梭状回和后扣带皮层的负相关是独特的。因此，我们描述了三种类固醇激素受体微卫星多态性的神经解剖学相关性及其与性别差异的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/84d655fb5e38/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/62b4ed9d9e83/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/1c941e3d6c96/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/34eacea361ed/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/84d655fb5e38/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/62b4ed9d9e83/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/1c941e3d6c96/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/34eacea361ed/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0711/8960998/84d655fb5e38/gr4.jpg

相似文献

1
The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.雌激素受体基因 ESR1、ESR2 和 AR 中的微卫星多态性对大脑结构性别差异的影响。
Neuroimage. 2020 Nov 1;221:117087. doi: 10.1016/j.neuroimage.2020.117087. Epub 2020 Jun 25.
2
Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women.雌激素受体 (ESR1、ESR2) 和雄激素受体 (AR) 基因中的微卫星与非裔美国人和尼日利亚女性的乳腺癌风险。
PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
3
Microsatellite variation of ESR1, ESR2, and AR in Serbian women with primary ovarian insufficiency.塞尔维亚原发性卵巢功能不全女性中雌激素受体1（ESR1）、雌激素受体2（ESR2）和雄激素受体（AR）的微卫星变异
Climacteric. 2018 Oct;21(5):472-477. doi: 10.1080/13697137.2018.1476967. Epub 2018 Aug 29.
4
Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer.雌激素受体α、β（ESR1、ESR2）和雄激素受体（AR）基因中的重复多态性与乳腺癌发生的关联。
Breast. 2008 Apr;17(2):159-66. doi: 10.1016/j.breast.2007.08.007. Epub 2007 Sep 29.
5
Hormonal parameters and sex hormone receptor gene polymorphisms in men with autoimmune diseases.自身免疫性疾病男性患者的激素参数和性激素受体基因多态性。
Rheumatol Int. 2013 Mar;33(3):575-82. doi: 10.1007/s00296-012-2386-4. Epub 2012 Mar 31.
6
Neuroendocrine stress response is moderated by sex and sex hormone receptor polymorphisms.神经内分泌应激反应受性别和性激素受体多态性的调节。
Horm Behav. 2018 Nov;106:74-80. doi: 10.1016/j.yhbeh.2018.10.002. Epub 2018 Oct 11.
7
Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy.甾体激素受体超家族基因多态性改变与绝经后激素治疗相关的绝经后乳腺癌风险。
Int J Cancer. 2010 Jun 15;126(12):2935-46. doi: 10.1002/ijc.24892.
8
Grey and white matter microstructure changes in epilepsy patients with vagus nerve stimulators.癫痫患者迷走神经刺激器治疗后灰质和白质微观结构的变化。
Clin Neurol Neurosurg. 2021 Oct;209:106918. doi: 10.1016/j.clineuro.2021.106918. Epub 2021 Aug 28.
9
Prostate cancer risk and ESR1 TA, ESR2 CA repeat polymorphisms.前列腺癌风险与雌激素受体1（ESR1）TA、雌激素受体2（ESR2）CA重复序列多态性
Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2233-6. doi: 10.1158/1055-9965.EPI-07-0481.
10
Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis.ESR1、ESR2 和 HSD17B1 基因的多态性与子宫内膜异位症的生育状态有关。
Gynecol Endocrinol. 2011 Jun;27(6):425-33. doi: 10.3109/09513590.2010.495434. Epub 2010 Jun 29.

引用本文的文献

1
Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety.产后抑郁症伴和不伴焦虑默认模式网络功能异常的分子基础。
Hum Brain Mapp. 2024 Apr;45(5):e26657. doi: 10.1002/hbm.26657.
2
Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection.自闭症患者大脑连接的性别相关性与代偿：女性保护的新见解。
Cereb Cortex. 2022 Dec 20;33(2):316-329. doi: 10.1093/cercor/bhac069.
3
Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.

本文引用的文献

1
Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease.ATXN1 和 AR 中的重复长度变化修饰了阿尔茨海默病的疾病表型。
Neurobiol Aging. 2019 Jan;73:230.e9-230.e17. doi: 10.1016/j.neurobiolaging.2018.09.007. Epub 2018 Sep 15.
2
Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants.成人大脑中的性别差异：来自 5216 名英国生物银行参与者的证据。
Cereb Cortex. 2018 Aug 1;28(8):2959-2975. doi: 10.1093/cercor/bhy109.
3
Unraveling age, puberty and testosterone effects on subcortical brain development across adolescence.
基于大脑的自闭症谱系障碍在整个生命周期中的性别差异：结构 MRI、fMRI 和 DTI 研究的系统综述。
Neuroimage Clin. 2021;31:102719. doi: 10.1016/j.nicl.2021.102719. Epub 2021 Jun 9.
4
Functional Analysis of Estrogen Receptor 1 in Diabetic Wound Healing: A Knockdown Cell-Based and Bioinformatic Study.雌激素受体 1 在糖尿病创面愈合中的功能分析：基于敲低细胞的和生物信息学研究。
Med Sci Monit. 2020 Dec 18;26:e928788. doi: 10.12659/MSM.928788.
揭示年龄、青春期和睾酮对青少年皮质下脑发育的影响。
Psychoneuroendocrinology. 2018 May;91:105-114. doi: 10.1016/j.psyneuen.2018.02.034. Epub 2018 Mar 8.
4
Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis.HER2与ESR2基因多态性和卵巢癌之间的遗传关联：一项荟萃分析。
Onco Targets Ther. 2018 Mar 1;11:1055-1066. doi: 10.2147/OTT.S149428. eCollection 2018.
5
Grey and white matter volumes either in treatment-naïve or hormone-treated transgender women: a voxel-based morphometry study.未接受治疗或激素治疗的跨性别女性的灰质和白质体积：基于体素的形态测量学研究。
Sci Rep. 2018 Jan 15;8(1):736. doi: 10.1038/s41598-017-17563-z.
6
Association between polymorphic CAG repeat lengths in the androgen receptor gene and susceptibility to prostate cancer: A systematic review and meta-analysis.雄激素受体基因中多态性CAG重复序列长度与前列腺癌易感性之间的关联：一项系统评价和荟萃分析。
Medicine (Baltimore). 2017 Jun;96(25):e7258. doi: 10.1097/MD.0000000000007258.
7
Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism.脑岛激活减弱反映出，作为睾酮给药与单胺氧化酶A基因多态性相互作用的结果，寻求风险和回报的行为增加。
Hum Brain Mapp. 2017 Sep;38(9):4574-4593. doi: 10.1002/hbm.23685. Epub 2017 Jun 12.
8
Developmental effects of androgens in the human brain.雄激素对人类大脑发育的影响。
J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12486.
9
Androgen receptor gene CAG repeat polymorphism and ovarian cancer risk: A meta-analysis.雄激素受体基因CAG重复多态性与卵巢癌风险：一项荟萃分析。
Biosci Trends. 2017 May 23;11(2):193-201. doi: 10.5582/bst.2016.01229. Epub 2017 Feb 28.
10
Subcortical gray matter changes in transgender subjects after long-term cross-sex hormone administration.长期接受跨性别激素治疗后跨性别者的皮质下灰质变化。
Psychoneuroendocrinology. 2016 Dec;74:371-379. doi: 10.1016/j.psyneuen.2016.09.028. Epub 2016 Oct 5.